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Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases
Bacterial quorum sensing (QS) is a cell-to-cell communication in which specific signals are activated to coordinate pathogenic behaviors and help bacteria acclimatize to the disadvantages. The QS signals in the bacteria mainly consist of acyl-homoserine lactone, autoinducing peptide, and autoinducer...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475571/ https://www.ncbi.nlm.nih.gov/pubmed/31080810 http://dx.doi.org/10.1155/2019/2015978 |
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author | Jiang, Qian Chen, Jiashun Yang, Chengbo Yin, Yulong Yao, Kang |
author_facet | Jiang, Qian Chen, Jiashun Yang, Chengbo Yin, Yulong Yao, Kang |
author_sort | Jiang, Qian |
collection | PubMed |
description | Bacterial quorum sensing (QS) is a cell-to-cell communication in which specific signals are activated to coordinate pathogenic behaviors and help bacteria acclimatize to the disadvantages. The QS signals in the bacteria mainly consist of acyl-homoserine lactone, autoinducing peptide, and autoinducer-2. QS signaling activation and biofilm formation lead to the antimicrobial resistance of the pathogens, thus increasing the therapy difficulty of bacterial diseases. Anti-QS agents can abolish the QS signaling and prevent the biofilm formation, therefore reducing bacterial virulence without causing drug-resistant to the pathogens, suggesting that anti-QS agents are potential alternatives for antibiotics. This review focuses on the anti-QS agents and their mediated signals in the pathogens and conveys the potential of QS targeted therapy for bacterial diseases. |
format | Online Article Text |
id | pubmed-6475571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-64755712019-05-12 Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases Jiang, Qian Chen, Jiashun Yang, Chengbo Yin, Yulong Yao, Kang Biomed Res Int Review Article Bacterial quorum sensing (QS) is a cell-to-cell communication in which specific signals are activated to coordinate pathogenic behaviors and help bacteria acclimatize to the disadvantages. The QS signals in the bacteria mainly consist of acyl-homoserine lactone, autoinducing peptide, and autoinducer-2. QS signaling activation and biofilm formation lead to the antimicrobial resistance of the pathogens, thus increasing the therapy difficulty of bacterial diseases. Anti-QS agents can abolish the QS signaling and prevent the biofilm formation, therefore reducing bacterial virulence without causing drug-resistant to the pathogens, suggesting that anti-QS agents are potential alternatives for antibiotics. This review focuses on the anti-QS agents and their mediated signals in the pathogens and conveys the potential of QS targeted therapy for bacterial diseases. Hindawi 2019-04-04 /pmc/articles/PMC6475571/ /pubmed/31080810 http://dx.doi.org/10.1155/2019/2015978 Text en Copyright © 2019 Qian Jiang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Jiang, Qian Chen, Jiashun Yang, Chengbo Yin, Yulong Yao, Kang Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases |
title | Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases |
title_full | Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases |
title_fullStr | Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases |
title_full_unstemmed | Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases |
title_short | Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases |
title_sort | quorum sensing: a prospective therapeutic target for bacterial diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475571/ https://www.ncbi.nlm.nih.gov/pubmed/31080810 http://dx.doi.org/10.1155/2019/2015978 |
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