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Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases

Bacterial quorum sensing (QS) is a cell-to-cell communication in which specific signals are activated to coordinate pathogenic behaviors and help bacteria acclimatize to the disadvantages. The QS signals in the bacteria mainly consist of acyl-homoserine lactone, autoinducing peptide, and autoinducer...

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Detalles Bibliográficos
Autores principales: Jiang, Qian, Chen, Jiashun, Yang, Chengbo, Yin, Yulong, Yao, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475571/
https://www.ncbi.nlm.nih.gov/pubmed/31080810
http://dx.doi.org/10.1155/2019/2015978
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author Jiang, Qian
Chen, Jiashun
Yang, Chengbo
Yin, Yulong
Yao, Kang
author_facet Jiang, Qian
Chen, Jiashun
Yang, Chengbo
Yin, Yulong
Yao, Kang
author_sort Jiang, Qian
collection PubMed
description Bacterial quorum sensing (QS) is a cell-to-cell communication in which specific signals are activated to coordinate pathogenic behaviors and help bacteria acclimatize to the disadvantages. The QS signals in the bacteria mainly consist of acyl-homoserine lactone, autoinducing peptide, and autoinducer-2. QS signaling activation and biofilm formation lead to the antimicrobial resistance of the pathogens, thus increasing the therapy difficulty of bacterial diseases. Anti-QS agents can abolish the QS signaling and prevent the biofilm formation, therefore reducing bacterial virulence without causing drug-resistant to the pathogens, suggesting that anti-QS agents are potential alternatives for antibiotics. This review focuses on the anti-QS agents and their mediated signals in the pathogens and conveys the potential of QS targeted therapy for bacterial diseases.
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spelling pubmed-64755712019-05-12 Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases Jiang, Qian Chen, Jiashun Yang, Chengbo Yin, Yulong Yao, Kang Biomed Res Int Review Article Bacterial quorum sensing (QS) is a cell-to-cell communication in which specific signals are activated to coordinate pathogenic behaviors and help bacteria acclimatize to the disadvantages. The QS signals in the bacteria mainly consist of acyl-homoserine lactone, autoinducing peptide, and autoinducer-2. QS signaling activation and biofilm formation lead to the antimicrobial resistance of the pathogens, thus increasing the therapy difficulty of bacterial diseases. Anti-QS agents can abolish the QS signaling and prevent the biofilm formation, therefore reducing bacterial virulence without causing drug-resistant to the pathogens, suggesting that anti-QS agents are potential alternatives for antibiotics. This review focuses on the anti-QS agents and their mediated signals in the pathogens and conveys the potential of QS targeted therapy for bacterial diseases. Hindawi 2019-04-04 /pmc/articles/PMC6475571/ /pubmed/31080810 http://dx.doi.org/10.1155/2019/2015978 Text en Copyright © 2019 Qian Jiang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jiang, Qian
Chen, Jiashun
Yang, Chengbo
Yin, Yulong
Yao, Kang
Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases
title Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases
title_full Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases
title_fullStr Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases
title_full_unstemmed Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases
title_short Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases
title_sort quorum sensing: a prospective therapeutic target for bacterial diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475571/
https://www.ncbi.nlm.nih.gov/pubmed/31080810
http://dx.doi.org/10.1155/2019/2015978
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