Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress

Ischemia/reperfusion injury (I/R) is one of the leading causes of acute kidney injury (AKI) that typically occurs in renal surgeries. However, renal I/R still currently lacks effective therapeutic targets. In this study, we proved that inhibition of Brd4 with its selective inhibitor, JQ1, could exer...

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Detalles Bibliográficos
Autores principales: Liu, Hao, Wang, Lei, Weng, Xiaodong, Chen, Hui, Du, Yang, Diao, Changhui, Chen, Zhiyuan, Liu, Xiuheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475721/
https://www.ncbi.nlm.nih.gov/pubmed/31004990
http://dx.doi.org/10.1016/j.redox.2019.101195

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