Dopamine receptor D(4) (DRD(4)) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia

OBJECTIVE: We aimed to understand the impact of dopamine receptor D(4) (DRD(4)) polymorphisms on neurodegeneration in patients with dementia. We hypothesized that DRD(4)dampened-variants with reduced functional potency would be associated with greater atrophy in regions with higher receptor density....

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Detalles Bibliográficos
Autores principales: Butler, P.M., Chiong, W., Perry, D.C., Miller, Z.A., Gennatas, E.D., Brown, J.A., Pasquini, L., Karydas, A., Dokuru, D., Coppola, G., Sturm, V.E., Boxer, A.L., Gorno-Tempini, M.L., Rosen, H.J., Kramer, J.H., Miller, B.L., Seeley, W.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475809/
https://www.ncbi.nlm.nih.gov/pubmed/31003069
http://dx.doi.org/10.1016/j.nicl.2019.101822

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