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Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion

OBJECTIVE: The inhalation anesthetic sevoflurane has presented numerous biological activities, including anti-inflammatory properties and protective effects against tissue ischemic injury. This study investigated the metabolic, hemodynamic, and inflammatory effects of sevoflurane pre- and postcondit...

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Autores principales: Figueira, Estela Regina Ramos, Rocha-Filho, Joel Avancini, Lanchotte, Cinthia, Coelho, Ana Maria Mendonça, Nakatani, Mauro, Tatebe, Eduardo Ryoiti, Lima, Jonathan Augusto Venceslau, Mendes, Camilla Oliveira, de Araujo, Bruno Camargo Rocha Paim, Abdo, Emilio Elias, D'Albuquerque, Luiz Carneiro, Galvão, Flavio Henrique Ferreira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476030/
https://www.ncbi.nlm.nih.gov/pubmed/31093276
http://dx.doi.org/10.1155/2019/5758984
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author Figueira, Estela Regina Ramos
Rocha-Filho, Joel Avancini
Lanchotte, Cinthia
Coelho, Ana Maria Mendonça
Nakatani, Mauro
Tatebe, Eduardo Ryoiti
Lima, Jonathan Augusto Venceslau
Mendes, Camilla Oliveira
de Araujo, Bruno Camargo Rocha Paim
Abdo, Emilio Elias
D'Albuquerque, Luiz Carneiro
Galvão, Flavio Henrique Ferreira
author_facet Figueira, Estela Regina Ramos
Rocha-Filho, Joel Avancini
Lanchotte, Cinthia
Coelho, Ana Maria Mendonça
Nakatani, Mauro
Tatebe, Eduardo Ryoiti
Lima, Jonathan Augusto Venceslau
Mendes, Camilla Oliveira
de Araujo, Bruno Camargo Rocha Paim
Abdo, Emilio Elias
D'Albuquerque, Luiz Carneiro
Galvão, Flavio Henrique Ferreira
author_sort Figueira, Estela Regina Ramos
collection PubMed
description OBJECTIVE: The inhalation anesthetic sevoflurane has presented numerous biological activities, including anti-inflammatory properties and protective effects against tissue ischemic injury. This study investigated the metabolic, hemodynamic, and inflammatory effects of sevoflurane pre- and postconditioning for short periods in the rescue of liver ischemia-reperfusion (IR) injury using a rat model. MATERIALS AND METHODS: Twenty Wistar rats were divided into four groups: sham group, control ischemia group (partial warm liver ischemia for 45 min followed by 4 h of reperfusion), SPC group (administration of sevoflurane 2.5% for 15 min with 5 min of washout before liver IR), and SPPoC group (administration of sevoflurane 2.5% for 15 min before ischemia and 20 min during reperfusion). RESULTS: All animals showed a decrease in the mean arterial pressure (MAP) and portal vein blood flow during ischemia. After 4 h of reperfusion, only the SPPoC group had MAP recovery. In both the SPC and SPPoC groups, there was a decrease in the ALT level and an increase in the bicarbonate and potassium serum levels. Only the SPPoC group showed an increase in the arterial blood ionized calcium level and a decrease in the IL-6 level after liver reperfusion. Therefore, this study demonstrated that sevoflurane preconditioning reduces hepatocellular injury and acid-base imbalance in liver ischemia. Furthermore, sevoflurane postconditioning promoted systemic hemodynamic recovery with a decrease in inflammatory response.
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spelling pubmed-64760302019-05-15 Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion Figueira, Estela Regina Ramos Rocha-Filho, Joel Avancini Lanchotte, Cinthia Coelho, Ana Maria Mendonça Nakatani, Mauro Tatebe, Eduardo Ryoiti Lima, Jonathan Augusto Venceslau Mendes, Camilla Oliveira de Araujo, Bruno Camargo Rocha Paim Abdo, Emilio Elias D'Albuquerque, Luiz Carneiro Galvão, Flavio Henrique Ferreira Gastroenterol Res Pract Research Article OBJECTIVE: The inhalation anesthetic sevoflurane has presented numerous biological activities, including anti-inflammatory properties and protective effects against tissue ischemic injury. This study investigated the metabolic, hemodynamic, and inflammatory effects of sevoflurane pre- and postconditioning for short periods in the rescue of liver ischemia-reperfusion (IR) injury using a rat model. MATERIALS AND METHODS: Twenty Wistar rats were divided into four groups: sham group, control ischemia group (partial warm liver ischemia for 45 min followed by 4 h of reperfusion), SPC group (administration of sevoflurane 2.5% for 15 min with 5 min of washout before liver IR), and SPPoC group (administration of sevoflurane 2.5% for 15 min before ischemia and 20 min during reperfusion). RESULTS: All animals showed a decrease in the mean arterial pressure (MAP) and portal vein blood flow during ischemia. After 4 h of reperfusion, only the SPPoC group had MAP recovery. In both the SPC and SPPoC groups, there was a decrease in the ALT level and an increase in the bicarbonate and potassium serum levels. Only the SPPoC group showed an increase in the arterial blood ionized calcium level and a decrease in the IL-6 level after liver reperfusion. Therefore, this study demonstrated that sevoflurane preconditioning reduces hepatocellular injury and acid-base imbalance in liver ischemia. Furthermore, sevoflurane postconditioning promoted systemic hemodynamic recovery with a decrease in inflammatory response. Hindawi 2019-04-07 /pmc/articles/PMC6476030/ /pubmed/31093276 http://dx.doi.org/10.1155/2019/5758984 Text en Copyright © 2019 Estela Regina Ramos Figueira et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Figueira, Estela Regina Ramos
Rocha-Filho, Joel Avancini
Lanchotte, Cinthia
Coelho, Ana Maria Mendonça
Nakatani, Mauro
Tatebe, Eduardo Ryoiti
Lima, Jonathan Augusto Venceslau
Mendes, Camilla Oliveira
de Araujo, Bruno Camargo Rocha Paim
Abdo, Emilio Elias
D'Albuquerque, Luiz Carneiro
Galvão, Flavio Henrique Ferreira
Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion
title Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion
title_full Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion
title_fullStr Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion
title_full_unstemmed Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion
title_short Sevoflurane Preconditioning plus Postconditioning Decreases Inflammatory Response with Hemodynamic Recovery in Experimental Liver Ischemia Reperfusion
title_sort sevoflurane preconditioning plus postconditioning decreases inflammatory response with hemodynamic recovery in experimental liver ischemia reperfusion
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476030/
https://www.ncbi.nlm.nih.gov/pubmed/31093276
http://dx.doi.org/10.1155/2019/5758984
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