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The role of intravenous acetaminophen in post‐operative pain control in head and neck cancer patients
OBJECTIVE: This study investigated the role of intravenous acetaminophen for alleviation of postoperative pain after surgical resection of head and neck cancers. METHODS: A single‐center study was conducted, which investigated a prospective group of 48 participants who underwent surgery between Apri...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476265/ https://www.ncbi.nlm.nih.gov/pubmed/31024996 http://dx.doi.org/10.1002/lio2.254 |
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author | Smith, Erin Lange, Jessica Moore, Cindy Eid, Isaam Jackson, Lana Monico, Jesus |
author_facet | Smith, Erin Lange, Jessica Moore, Cindy Eid, Isaam Jackson, Lana Monico, Jesus |
author_sort | Smith, Erin |
collection | PubMed |
description | OBJECTIVE: This study investigated the role of intravenous acetaminophen for alleviation of postoperative pain after surgical resection of head and neck cancers. METHODS: A single‐center study was conducted, which investigated a prospective group of 48 participants who underwent surgery between April 2016 and May 2017 and postoperatively received scheduled IV acetaminophen (1 g every 6 hours for 4 doses) plus the standard opioid PCA and breakthrough narcotics. These were compared to a similar retrospective cohort of 51 patients who had surgery between January 2014 to March 2015 and only received an opioid patient controlled analgesia (PCA) pump and breakthrough narcotics. Outcome measures included averaged pain scores, total amount of narcotics received (in morphine equivalents), and number of PCA attempts measured in 8‐hour intervals over the first 24 hours, as well as duration of PCA and length of stay. Statistical measures included descriptive analysis and gamma regression analysis. RESULTS: The acetaminophen group achieved equally low pain scores (0.8 ± 1.2 vs. 1.0 ± 1.3, P = .408) with significantly less total narcotics in the first 8 hours after surgery (13.5 ± 13.3 vs. 22.5 ± 21.5 MEs, P = .014). This group had a significantly decreased length of stay (7.8 ± 4.6 vs. 10.6 ± 7.6 days, P = .03). CONCLUSION: This study demonstrates that intravenous acetaminophen may play a role in reducing the total narcotic requirement in the first 8 hours after surgery and contribute to a decreased length of stay and potentially decrease cost to the patient and hospital overall. Future research should be aimed at comparing these groups in a randomized control study/setting. LEVEL OF EVIDENCE: 3 |
format | Online Article Text |
id | pubmed-6476265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64762652019-04-25 The role of intravenous acetaminophen in post‐operative pain control in head and neck cancer patients Smith, Erin Lange, Jessica Moore, Cindy Eid, Isaam Jackson, Lana Monico, Jesus Laryngoscope Investig Otolaryngol Head, Neck, and Tumor Biology OBJECTIVE: This study investigated the role of intravenous acetaminophen for alleviation of postoperative pain after surgical resection of head and neck cancers. METHODS: A single‐center study was conducted, which investigated a prospective group of 48 participants who underwent surgery between April 2016 and May 2017 and postoperatively received scheduled IV acetaminophen (1 g every 6 hours for 4 doses) plus the standard opioid PCA and breakthrough narcotics. These were compared to a similar retrospective cohort of 51 patients who had surgery between January 2014 to March 2015 and only received an opioid patient controlled analgesia (PCA) pump and breakthrough narcotics. Outcome measures included averaged pain scores, total amount of narcotics received (in morphine equivalents), and number of PCA attempts measured in 8‐hour intervals over the first 24 hours, as well as duration of PCA and length of stay. Statistical measures included descriptive analysis and gamma regression analysis. RESULTS: The acetaminophen group achieved equally low pain scores (0.8 ± 1.2 vs. 1.0 ± 1.3, P = .408) with significantly less total narcotics in the first 8 hours after surgery (13.5 ± 13.3 vs. 22.5 ± 21.5 MEs, P = .014). This group had a significantly decreased length of stay (7.8 ± 4.6 vs. 10.6 ± 7.6 days, P = .03). CONCLUSION: This study demonstrates that intravenous acetaminophen may play a role in reducing the total narcotic requirement in the first 8 hours after surgery and contribute to a decreased length of stay and potentially decrease cost to the patient and hospital overall. Future research should be aimed at comparing these groups in a randomized control study/setting. LEVEL OF EVIDENCE: 3 John Wiley and Sons Inc. 2019-02-11 /pmc/articles/PMC6476265/ /pubmed/31024996 http://dx.doi.org/10.1002/lio2.254 Text en © 2019 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Head, Neck, and Tumor Biology Smith, Erin Lange, Jessica Moore, Cindy Eid, Isaam Jackson, Lana Monico, Jesus The role of intravenous acetaminophen in post‐operative pain control in head and neck cancer patients |
title | The role of intravenous acetaminophen in post‐operative pain control in head and neck cancer patients |
title_full | The role of intravenous acetaminophen in post‐operative pain control in head and neck cancer patients |
title_fullStr | The role of intravenous acetaminophen in post‐operative pain control in head and neck cancer patients |
title_full_unstemmed | The role of intravenous acetaminophen in post‐operative pain control in head and neck cancer patients |
title_short | The role of intravenous acetaminophen in post‐operative pain control in head and neck cancer patients |
title_sort | role of intravenous acetaminophen in post‐operative pain control in head and neck cancer patients |
topic | Head, Neck, and Tumor Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476265/ https://www.ncbi.nlm.nih.gov/pubmed/31024996 http://dx.doi.org/10.1002/lio2.254 |
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