Cargando…

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin

Ancient organisms have a combined coagulation and immune system, and although links between inflammation and hemostasis exist in mammals, they are indirect and slower to act. Here we investigated direct links between mammalian immune and coagulation systems by examining cytokine proproteins for pote...

Descripción completa

Detalles Bibliográficos
Autores principales:	Burzynski, Laura C., Humphry, Melanie, Pyrillou, Katerina, Wiggins, Kimberley A., Chan, Julie N.E., Figg, Nichola, Kitt, Lauren L., Summers, Charlotte, Tatham, Kate C., Martin, Paul B., Bennett, Martin R., Clarke, Murray C.H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476404/ https://www.ncbi.nlm.nih.gov/pubmed/30926232 http://dx.doi.org/10.1016/j.immuni.2019.03.003

Ejemplares similares

Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production
por: Burzynski, Laura C, et al.
Publicado: (2023)

Interleukin-1α Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2: IMPLICATIONS FOR ALLOGRAFT REJECTION
por: Burzynski, Laura C., et al.
Publicado: (2015)

Alternative Pathways of IL-1 Activation, and Its Role in Health and Disease
por: Pyrillou, Katerina, et al.
Publicado: (2020)

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation
por: Zheng, Yue, et al.
Publicado: (2013)

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory Phenotype
por: Gardner, Sarah E., et al.
Publicado: (2015)

Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells
por: Aravani, Dimitra, et al.
Publicado: (2020)

Senescence utilises inflammatory caspases to drive SASP
por: Wiggins, Kimberley A., et al.
Publicado: (2019)

Thrombin generation: a global coagulation procedure to investigate hypo- and hyper-coagulability
por: Tripodi, Armando
Publicado: (2020)

Deciphering the coagulation profile through the dynamics of thrombin activity
por: de Laat-Kremers, Romy M. W., et al.
Publicado: (2020)

STUDIES ON BLOOD COAGULATION : III. ON THE CONSTANCY OF THE HYDROGEN ION CONCENTRATION DURING THE COAGULATION OF FIBRINOGEN BY THROMBIN
por: Eagle, Harry, et al.
Publicado: (1935)

Thrombin and factor Xa link the coagulation system with liver fibrosis
por: Dhar, Ameet, et al.
Publicado: (2018)

STUDIES ON BLOOD COAGULATION : II. THE FORMATION OF FIBRIN FROM THROMBIN AND FIBRINOGEN
por: Eagle, Harry
Publicado: (1935)

STUDIES ON BLOOD COAGULATION : I. THE RÔLE OF PROTHROMBIN AND OF PLATELETS IN THE FORMATION OF THROMBIN
por: Eagle, Harry
Publicado: (1935)

Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond
por: Danckwardt, Sven, et al.
Publicado: (2013)

Coagulation Factor XII Levels and Intrinsic Thrombin Generation in Multiple Sclerosis
por: Ziliotto, Nicole, et al.
Publicado: (2018)

Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies
por: Slatter, David A., et al.
Publicado: (2018)

Intrinsic coagulation pathway-mediated thrombin generation in mouse whole blood
por: Konrath, Sandra, et al.
Publicado: (2022)

In vitro anti-inflammatory and anti-coagulant effects of antibiotics towards Platelet Activating Factor and thrombin
por: Tsoupras, Alexandros B, et al.
Publicado: (2011)

Imbalance in Coagulation/Fibrinolysis Inhibitors Resulting in Extravascular Thrombin Generation in Gliomas of Varying Levels of Malignancy
por: Wojtukiewicz, Marek Z., et al.
Publicado: (2021)

Hemostasis, coagulation and thrombin in venoarterial and venovenous extracorporeal membrane oxygenation: the HECTIC study
por: Cartwright, Bruce, et al.
Publicado: (2021)

Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation
por: Parunov, Leonid A., et al.
Publicado: (2023)

IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype
por: Wiggins, Kimberley A., et al.
Publicado: (2019)

Coagulation Proteins Influencing Global Coagulation Assays in Cirrhosis: Hypercoagulability in Cirrhosis Assessed by Thrombomodulin-Induced Thrombin Generation Assay
por: Youngwon, Nam, et al.
Publicado: (2013)

New High-Affinity Thrombin Aptamers for Advancing Coagulation Therapy: Balancing Thrombin Inhibition for Clot Prevention and Effective Bleeding Management with Antidote
por: Ayass, Mohamad Ammar, et al.
Publicado: (2023)

Host Defense Peptides of Thrombin Modulate Inflammation and Coagulation in Endotoxin-Mediated Shock and Pseudomonas aeruginosa Sepsis
por: Kalle, Martina, et al.
Publicado: (2012)

The REMDACTA trial: do interleukin receptor antagonists provide additional benefit in COVID-19?
por: Tatham, Kate C., et al.
Publicado: (2021)

Defective Base Excision Repair of Oxidative DNA Damage in Vascular Smooth Muscle Cells Promotes Atherosclerosis
por: Shah, Aarti, et al.
Publicado: (2018)

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
por: Cassidy, Liam D., et al.
Publicado: (2020)

Thrombin formation via the intrinsic coagulation pathway and von Willebrand factor reflect disease severity in COVID-19
por: Busch, Matthias H., et al.
Publicado: (2022)

Thrombin-activatable fibrinolysis inhibitor and organ dysfunction in disseminated intravascular coagulation associated with sepsis
por: Hayakawa, M, et al.
Publicado: (2011)

Systems Biology of Coagulation Initiation: Kinetics of Thrombin Generation in Resting and Activated Human Blood
por: Chatterjee, Manash S., et al.
Publicado: (2010)

HIV Replication Alters the Composition of Extrinsic Pathway Coagulation Factors and Increases Thrombin Generation
por: Baker, Jason V., et al.
Publicado: (2013)

The Organophosphate Paraoxon and Its Antidote Obidoxime Inhibit Thrombin Activity and Affect Coagulation In Vitro
por: Golderman, Valery, et al.
Publicado: (2016)

The Coagulation Factors Fibrinogen, Thrombin, and Factor XII in Inflammatory Disorders—A Systematic Review
por: Göbel, Kerstin, et al.
Publicado: (2018)

Activation of blood coagulation and thrombin generation in acute ischemic stroke treated with rtPA
por: Goldman, Sarah, et al.
Publicado: (2017)

Thrombin, a Mediator of Coagulation, Inflammation, and Neurotoxicity at the Neurovascular Interface: Implications for Alzheimer’s Disease
por: Iannucci, Jaclyn, et al.
Publicado: (2020)

The neuro-glial coagulonome: the thrombin receptor and coagulation pathways as major players in neurological diseases
por: Gofrit, Shany G., et al.
Publicado: (2019)

Human endothelial cells and fibroblasts express and produce the coagulation proteins necessary for thrombin generation
por: Cohen, Clay T., et al.
Publicado: (2021)

Adhesive Virulence Factors of Staphylococcus aureus Resist Digestion by Coagulation Proteases Thrombin and Plasmin
por: Risser, Fanny, et al.
Publicado: (2022)

Relationships between coagulation factors and thrombin generation in a general population with arterial and venous disease background
por: van Paridon, Pauline C. S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3j9gljn4ouad0ssk9mscf9mt7d