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Oxidative stress causes Alu RNA accumulation via PIWIL4 sequestration into stress granules

The Alu element, the most abundant transposable element, is transcribed to Alu RNA. We hypothesized that the PIWI protein regulates the expression of Alu RNA in retinal pigment epithelial (RPE) cells, where accumulated Alu RNA leads to macular degeneration. Alu transcription was induced in RPE cells...

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Detalles Bibliográficos
Autores principales:	Hwang, Yeo Eun, Baek, Yu Mi, Baek, Ahruem, Kim, Dong-Eun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476485/ https://www.ncbi.nlm.nih.gov/pubmed/30103846 http://dx.doi.org/10.5483/BMBRep.2019.52.3.146

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