Arsenite malignantly transforms human prostate epithelial cells in vitro by gene amplification of mutated KRAS

Inorganic arsenic is an environmental human carcinogen of several organs including the urinary tract. RWPE-1 cells are immortalized, non-tumorigenic, human prostate epithelia that become malignantly transformed into the CAsE-PE line after continuous in vitro exposure to 5μM arsenite over a period of...

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Detalles Bibliográficos
Autores principales: Merrick, B. Alex, Phadke, Dhiral P., Bostrom, Meredith A., Shah, Ruchir R., Wright, Garron M., Wang, Xinguo, Gordon, Oksana, Pelch, Katherine E., Auerbach, Scott S., Paules, Richard S., DeVito, Michael J., Waalkes, Michael P., Tokar, Erik J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476498/
https://www.ncbi.nlm.nih.gov/pubmed/31009485
http://dx.doi.org/10.1371/journal.pone.0215504

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