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Herpes simplex virus type 1 epidemiology in Latin America and the Caribbean: Systematic review and meta-analytics
OBJECTIVES: To investigate the epidemiology of herpes simplex virus type 1 (HSV-1) in Latin America and the Caribbean. METHODS: Systematic review and meta-analytics guided by the Cochrane Collaboration Handbook and reported following the PRISMA guidelines. RESULTS: Thirty-three relevant reports were...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476500/ https://www.ncbi.nlm.nih.gov/pubmed/31009486 http://dx.doi.org/10.1371/journal.pone.0215487 |
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author | Sukik, Layan Alyafei, Maryam Harfouche, Manale Abu-Raddad, Laith J. |
author_facet | Sukik, Layan Alyafei, Maryam Harfouche, Manale Abu-Raddad, Laith J. |
author_sort | Sukik, Layan |
collection | PubMed |
description | OBJECTIVES: To investigate the epidemiology of herpes simplex virus type 1 (HSV-1) in Latin America and the Caribbean. METHODS: Systematic review and meta-analytics guided by the Cochrane Collaboration Handbook and reported following the PRISMA guidelines. RESULTS: Thirty-three relevant reports were identified including 35 overall (and 95 stratified) seroprevalence measures, and five and nine proportions of virus isolation in genital ulcer disease (GUD) and in genital herpes, respectively. Pooled mean seroprevalence was 57.2% (95% CI: 49.7–64.6%) among children and 88.4% (95% CI: 85.2–91.2%) among adults. Pooled mean seroprevalence was lowest at 49.7% (95% CI: 42.8–56.6%) in those aged ≤10, followed by 77.8% (95% CI: 67.9–84.8%) in those aged 10–20, 82.8% (95% CI: 73.1–90.8%) in those aged 20–30, 92.5% (95% CI: 89.4–95.1%) in those aged 30–40, and 94.2% (95% CI: 92.7–95.5%) in those aged ≥40. Age was the strongest source of heterogeneity in seroprevalence, explaining 54% of variation. Evidence was found for seroprevalence decline over time. Pooled mean proportion of HSV-1 isolation was 0.9% (95% CI: 0.0–3.6%) in GUD and 10.9% (95% CI: 4.4–19.4%) in genital herpes. CONCLUSIONS: HSV-1 is a widely prevalent infection in this region, but its epidemiology may be slowly transitioning, with still limited contribution for HSV-1 in genital herpes. |
format | Online Article Text |
id | pubmed-6476500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-64765002019-05-07 Herpes simplex virus type 1 epidemiology in Latin America and the Caribbean: Systematic review and meta-analytics Sukik, Layan Alyafei, Maryam Harfouche, Manale Abu-Raddad, Laith J. PLoS One Research Article OBJECTIVES: To investigate the epidemiology of herpes simplex virus type 1 (HSV-1) in Latin America and the Caribbean. METHODS: Systematic review and meta-analytics guided by the Cochrane Collaboration Handbook and reported following the PRISMA guidelines. RESULTS: Thirty-three relevant reports were identified including 35 overall (and 95 stratified) seroprevalence measures, and five and nine proportions of virus isolation in genital ulcer disease (GUD) and in genital herpes, respectively. Pooled mean seroprevalence was 57.2% (95% CI: 49.7–64.6%) among children and 88.4% (95% CI: 85.2–91.2%) among adults. Pooled mean seroprevalence was lowest at 49.7% (95% CI: 42.8–56.6%) in those aged ≤10, followed by 77.8% (95% CI: 67.9–84.8%) in those aged 10–20, 82.8% (95% CI: 73.1–90.8%) in those aged 20–30, 92.5% (95% CI: 89.4–95.1%) in those aged 30–40, and 94.2% (95% CI: 92.7–95.5%) in those aged ≥40. Age was the strongest source of heterogeneity in seroprevalence, explaining 54% of variation. Evidence was found for seroprevalence decline over time. Pooled mean proportion of HSV-1 isolation was 0.9% (95% CI: 0.0–3.6%) in GUD and 10.9% (95% CI: 4.4–19.4%) in genital herpes. CONCLUSIONS: HSV-1 is a widely prevalent infection in this region, but its epidemiology may be slowly transitioning, with still limited contribution for HSV-1 in genital herpes. Public Library of Science 2019-04-22 /pmc/articles/PMC6476500/ /pubmed/31009486 http://dx.doi.org/10.1371/journal.pone.0215487 Text en © 2019 Sukik et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sukik, Layan Alyafei, Maryam Harfouche, Manale Abu-Raddad, Laith J. Herpes simplex virus type 1 epidemiology in Latin America and the Caribbean: Systematic review and meta-analytics |
title | Herpes simplex virus type 1 epidemiology in Latin America and the Caribbean: Systematic review and meta-analytics |
title_full | Herpes simplex virus type 1 epidemiology in Latin America and the Caribbean: Systematic review and meta-analytics |
title_fullStr | Herpes simplex virus type 1 epidemiology in Latin America and the Caribbean: Systematic review and meta-analytics |
title_full_unstemmed | Herpes simplex virus type 1 epidemiology in Latin America and the Caribbean: Systematic review and meta-analytics |
title_short | Herpes simplex virus type 1 epidemiology in Latin America and the Caribbean: Systematic review and meta-analytics |
title_sort | herpes simplex virus type 1 epidemiology in latin america and the caribbean: systematic review and meta-analytics |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476500/ https://www.ncbi.nlm.nih.gov/pubmed/31009486 http://dx.doi.org/10.1371/journal.pone.0215487 |
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