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Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos

OBJECTIVE: Hispanics/Latinos have some of the highest prevalence rates for cardiovascular disease risk factors, but stark differences exist by self-reported background. Cardiovascular disease risk factors negatively impact cognition in Hispanics/Latinos; less is known about these relationships by Hi...

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Autores principales: Lamar, Melissa, Durazo-Arvizu, Ramon A., Sachdeva, Shruti, Pirzada, Amber, Perreira, Krista M., Rundek, Tatjana, Gallo, Linda C., Grober, Ellen, DeCarli, Charles, Lipton, Richard B., Tarraf, Wassim, González, Hector M., Daviglus, Martha L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476505/
https://www.ncbi.nlm.nih.gov/pubmed/31009492
http://dx.doi.org/10.1371/journal.pone.0215378
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author Lamar, Melissa
Durazo-Arvizu, Ramon A.
Sachdeva, Shruti
Pirzada, Amber
Perreira, Krista M.
Rundek, Tatjana
Gallo, Linda C.
Grober, Ellen
DeCarli, Charles
Lipton, Richard B.
Tarraf, Wassim
González, Hector M.
Daviglus, Martha L.
author_facet Lamar, Melissa
Durazo-Arvizu, Ramon A.
Sachdeva, Shruti
Pirzada, Amber
Perreira, Krista M.
Rundek, Tatjana
Gallo, Linda C.
Grober, Ellen
DeCarli, Charles
Lipton, Richard B.
Tarraf, Wassim
González, Hector M.
Daviglus, Martha L.
author_sort Lamar, Melissa
collection PubMed
description OBJECTIVE: Hispanics/Latinos have some of the highest prevalence rates for cardiovascular disease risk factors, but stark differences exist by self-reported background. Cardiovascular disease risk factors negatively impact cognition in Hispanics/Latinos; less is known about these relationships by Hispanic/Latino backgrounds. We investigated cognitive associations with cardiovascular disease risk factor burden in a diverse cohort, the Hispanic Community Health Study/Study of Latinos. METHODS: Baseline data from this observational study of cardiovascular disease and its antecedents was collected from 2008–2011. We included 7,121 participants 45–74 years old from Central American, Cuban, Dominican, Mexican, Puerto Rican, or South American backgrounds. Dichotomous indicators for hypertension, diabetes, hypercholesterolemia, obesity, and smoking were evaluated and totaled, with participants grouped by lowest (0–2), middle (3) or highest (4–5) burden. Cognitive testing included the Brief Spanish English Verbal Learning Test, letter fluency, and digit symbol substitution. RESULTS: In separate fully-adjusted linear regression models, lower fluency and digit symbol substitution performance were restricted to the highest compared to the lowest burden group; whereas the middle burden group displayed impaired memory performance compared to the lowest burden group (p-values≤0.05). Background interacted with burden for learning and memory performance. That is, the association of burden level (i.e., lowest, middle, or highest) with cognitive performance was modified by background (e.g., Mexicans vs Cuban). CONCLUSIONS: Hispanics/Latinos with higher levels of cardiovascular disease risk factor burden displayed lower levels of cognitive performance, with learning and memory performance modified by background.
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spelling pubmed-64765052019-05-07 Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos Lamar, Melissa Durazo-Arvizu, Ramon A. Sachdeva, Shruti Pirzada, Amber Perreira, Krista M. Rundek, Tatjana Gallo, Linda C. Grober, Ellen DeCarli, Charles Lipton, Richard B. Tarraf, Wassim González, Hector M. Daviglus, Martha L. PLoS One Research Article OBJECTIVE: Hispanics/Latinos have some of the highest prevalence rates for cardiovascular disease risk factors, but stark differences exist by self-reported background. Cardiovascular disease risk factors negatively impact cognition in Hispanics/Latinos; less is known about these relationships by Hispanic/Latino backgrounds. We investigated cognitive associations with cardiovascular disease risk factor burden in a diverse cohort, the Hispanic Community Health Study/Study of Latinos. METHODS: Baseline data from this observational study of cardiovascular disease and its antecedents was collected from 2008–2011. We included 7,121 participants 45–74 years old from Central American, Cuban, Dominican, Mexican, Puerto Rican, or South American backgrounds. Dichotomous indicators for hypertension, diabetes, hypercholesterolemia, obesity, and smoking were evaluated and totaled, with participants grouped by lowest (0–2), middle (3) or highest (4–5) burden. Cognitive testing included the Brief Spanish English Verbal Learning Test, letter fluency, and digit symbol substitution. RESULTS: In separate fully-adjusted linear regression models, lower fluency and digit symbol substitution performance were restricted to the highest compared to the lowest burden group; whereas the middle burden group displayed impaired memory performance compared to the lowest burden group (p-values≤0.05). Background interacted with burden for learning and memory performance. That is, the association of burden level (i.e., lowest, middle, or highest) with cognitive performance was modified by background (e.g., Mexicans vs Cuban). CONCLUSIONS: Hispanics/Latinos with higher levels of cardiovascular disease risk factor burden displayed lower levels of cognitive performance, with learning and memory performance modified by background. Public Library of Science 2019-04-22 /pmc/articles/PMC6476505/ /pubmed/31009492 http://dx.doi.org/10.1371/journal.pone.0215378 Text en © 2019 Lamar et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lamar, Melissa
Durazo-Arvizu, Ramon A.
Sachdeva, Shruti
Pirzada, Amber
Perreira, Krista M.
Rundek, Tatjana
Gallo, Linda C.
Grober, Ellen
DeCarli, Charles
Lipton, Richard B.
Tarraf, Wassim
González, Hector M.
Daviglus, Martha L.
Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos
title Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos
title_full Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos
title_fullStr Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos
title_full_unstemmed Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos
title_short Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos
title_sort cardiovascular disease risk factor burden and cognition: implications of ethnic diversity within the hispanic community health study/study of latinos
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476505/
https://www.ncbi.nlm.nih.gov/pubmed/31009492
http://dx.doi.org/10.1371/journal.pone.0215378
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