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An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape

Characterizing the fitness landscape, a representation of fitness for a large set of genotypes, is key to understanding how genetic information is interpreted to create functional organisms. Here we determined the evolutionarily-relevant segment of the fitness landscape of His3, a gene coding for an...

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Detalles Bibliográficos
Autores principales:	Pokusaeva, Victoria O., Usmanova, Dinara R., Putintseva, Ekaterina V., Espinar, Lorena, Sarkisyan, Karen S., Mishin, Alexander S., Bogatyreva, Natalya S., Ivankov, Dmitry N., Akopyan, Arseniy V., Avvakumov, Sergey Ya., Povolotskaya, Inna S., Filion, Guillaume J., Carey, Lucas B., Kondrashov, Fyodor A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476524/ https://www.ncbi.nlm.nih.gov/pubmed/30969963 http://dx.doi.org/10.1371/journal.pgen.1008079

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