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Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies

The SWI/SNF-family chromatin remodeling protein ATRX is a tumor suppressor in sarcomas, gliomas and other malignancies. Its loss of function facilitates the alternative lengthening of telomeres (ALT) pathway in tumor cells, while it also affects Polycomb repressive complex 2 (PRC2) silencing of its...

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Detalles Bibliográficos
Autores principales:	Oppel, Felix, Tao, Ting, Shi, Hui, Ross, Kenneth N., Zimmerman, Mark W., He, Shuning, Tong, Guangxiang, Aster, Jon C., Look, A. Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476535/ https://www.ncbi.nlm.nih.gov/pubmed/30970016 http://dx.doi.org/10.1371/journal.pgen.1008039

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