Nivolumab-induced myocardial necrosis in a patient with lung cancer: A case report

A 74-year-old man with lung adenocarcinoma recurrence was admitted to our hospital because of dyspnea 7 days after receiving initial immunotherapy with nivolumab. Electrocardiography revealed ST-segment elevation in V1-6 and echocardiography showed a markedly reduced left ventricular ejection fracti...

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Detalles Bibliográficos
Autores principales: Sakai, Takashi, Yahagi, Kazuyuki, Hoshino, Tatsuhiro, Yokota, Toshiya, Tanabe, Kengo, Mori, Masaya, Ikeda, Shingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476808/
https://www.ncbi.nlm.nih.gov/pubmed/31024792
http://dx.doi.org/10.1016/j.rmcr.2019.100839
Descripción
Sumario:A 74-year-old man with lung adenocarcinoma recurrence was admitted to our hospital because of dyspnea 7 days after receiving initial immunotherapy with nivolumab. Electrocardiography revealed ST-segment elevation in V1-6 and echocardiography showed a markedly reduced left ventricular ejection fraction of 9% and akinesis of the anteroseptal wall and apex. He died from acute heart failure 3 days after admission. Microscopically, multiple small foci of myocardial necrosis with few inflammatory cells were scattered in both ventricles. Obstruction of the coronary artery was not identified. We believed that the cause of death was acute heart failure possibly due to nivolumab-induced myocardial necrosis.

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