Nivolumab-induced myocardial necrosis in a patient with lung cancer: A case report

A 74-year-old man with lung adenocarcinoma recurrence was admitted to our hospital because of dyspnea 7 days after receiving initial immunotherapy with nivolumab. Electrocardiography revealed ST-segment elevation in V1-6 and echocardiography showed a markedly reduced left ventricular ejection fracti...

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Autores principales: Sakai, Takashi, Yahagi, Kazuyuki, Hoshino, Tatsuhiro, Yokota, Toshiya, Tanabe, Kengo, Mori, Masaya, Ikeda, Shingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476808/
https://www.ncbi.nlm.nih.gov/pubmed/31024792
http://dx.doi.org/10.1016/j.rmcr.2019.100839
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author Sakai, Takashi
Yahagi, Kazuyuki
Hoshino, Tatsuhiro
Yokota, Toshiya
Tanabe, Kengo
Mori, Masaya
Ikeda, Shingo
author_facet Sakai, Takashi
Yahagi, Kazuyuki
Hoshino, Tatsuhiro
Yokota, Toshiya
Tanabe, Kengo
Mori, Masaya
Ikeda, Shingo
author_sort Sakai, Takashi
collection PubMed
description A 74-year-old man with lung adenocarcinoma recurrence was admitted to our hospital because of dyspnea 7 days after receiving initial immunotherapy with nivolumab. Electrocardiography revealed ST-segment elevation in V1-6 and echocardiography showed a markedly reduced left ventricular ejection fraction of 9% and akinesis of the anteroseptal wall and apex. He died from acute heart failure 3 days after admission. Microscopically, multiple small foci of myocardial necrosis with few inflammatory cells were scattered in both ventricles. Obstruction of the coronary artery was not identified. We believed that the cause of death was acute heart failure possibly due to nivolumab-induced myocardial necrosis.
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spelling pubmed-64768082019-04-25 Nivolumab-induced myocardial necrosis in a patient with lung cancer: A case report Sakai, Takashi Yahagi, Kazuyuki Hoshino, Tatsuhiro Yokota, Toshiya Tanabe, Kengo Mori, Masaya Ikeda, Shingo Respir Med Case Rep Article A 74-year-old man with lung adenocarcinoma recurrence was admitted to our hospital because of dyspnea 7 days after receiving initial immunotherapy with nivolumab. Electrocardiography revealed ST-segment elevation in V1-6 and echocardiography showed a markedly reduced left ventricular ejection fraction of 9% and akinesis of the anteroseptal wall and apex. He died from acute heart failure 3 days after admission. Microscopically, multiple small foci of myocardial necrosis with few inflammatory cells were scattered in both ventricles. Obstruction of the coronary artery was not identified. We believed that the cause of death was acute heart failure possibly due to nivolumab-induced myocardial necrosis. Elsevier 2019-04-15 /pmc/articles/PMC6476808/ /pubmed/31024792 http://dx.doi.org/10.1016/j.rmcr.2019.100839 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Sakai, Takashi
Yahagi, Kazuyuki
Hoshino, Tatsuhiro
Yokota, Toshiya
Tanabe, Kengo
Mori, Masaya
Ikeda, Shingo
Nivolumab-induced myocardial necrosis in a patient with lung cancer: A case report
title Nivolumab-induced myocardial necrosis in a patient with lung cancer: A case report
title_full Nivolumab-induced myocardial necrosis in a patient with lung cancer: A case report
title_fullStr Nivolumab-induced myocardial necrosis in a patient with lung cancer: A case report
title_full_unstemmed Nivolumab-induced myocardial necrosis in a patient with lung cancer: A case report
title_short Nivolumab-induced myocardial necrosis in a patient with lung cancer: A case report
title_sort nivolumab-induced myocardial necrosis in a patient with lung cancer: a case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476808/
https://www.ncbi.nlm.nih.gov/pubmed/31024792
http://dx.doi.org/10.1016/j.rmcr.2019.100839
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