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The inhibition of thymidine phosphorylase can reverse acquired 5FU-resistance in gastric cancer cells

BACKGROUND: 5FU can be converted to its active metabolite fluoro-deoxyuridine monophosphate (FdUMP) through two pathways: the orotate phosphoribosyl transferase–ribonucleotide reductase (OPRT–RR) pathway and the thymidine phosphorylase–thymidine kinase (TP–TK) pathway. We investigated the mechanism...

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Detalles Bibliográficos
Autores principales:	Mori, Ryutaro, Yoshida, Kazuhiro, Futamura, Manabu, Suetsugu, Tomonari, Shizu, Kaoru, Tanahashi, Toshiyuki, Tanaka, Yoshihiro, Matsuhashi, Nobuhisha, Yamaguchi, Kazuya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476841/ https://www.ncbi.nlm.nih.gov/pubmed/30276573 http://dx.doi.org/10.1007/s10120-018-0881-3

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