Design and synthesis of anticancer 1-hydroxynaphthalene-2-carboxanilides with a p53 independent mechanism of action

A series of 116 small-molecule 1-hydroxynaphthalene-2-carboxanilides was designed based on the fragment-based approach and was synthesized according to the microwave-assisted protocol. The biological activity of all of the compounds was tested on human colon carcinoma cell lines including a deleted...

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Detalles Bibliográficos
Autores principales: Spaczyńska, Ewelina, Mrozek-Wilczkiewicz, Anna, Malarz, Katarzyna, Kos, Jiri, Gonec, Tomas, Oravec, Michal, Gawecki, Robert, Bak, Andrzej, Dohanosova, Jana, Kapustikova, Iva, Liptaj, Tibor, Jampilek, Josef, Musiol, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476888/
https://www.ncbi.nlm.nih.gov/pubmed/31011161
http://dx.doi.org/10.1038/s41598-019-42595-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476888/
https://www.ncbi.nlm.nih.gov/pubmed/31011161
http://dx.doi.org/10.1038/s41598-019-42595-y

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