Structural Vaccinology for Viral Vaccine Design

Although vaccines have proven pivotal against arrays of infectious viral diseases, there are still no effective vaccines against many viruses. New structural insights into the viral envelope, protein conformation, and antigenic epitopes can guide the design of novel vaccines against challenging viru...

Descripción completa

Detalles Bibliográficos
Autores principales: Anasir, Mohd Ishtiaq, Poh, Chit Laa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476906/
https://www.ncbi.nlm.nih.gov/pubmed/31040832
http://dx.doi.org/10.3389/fmicb.2019.00738
_version_ 1783412957174038528
author Anasir, Mohd Ishtiaq
Poh, Chit Laa
author_facet Anasir, Mohd Ishtiaq
Poh, Chit Laa
author_sort Anasir, Mohd Ishtiaq
collection PubMed
description Although vaccines have proven pivotal against arrays of infectious viral diseases, there are still no effective vaccines against many viruses. New structural insights into the viral envelope, protein conformation, and antigenic epitopes can guide the design of novel vaccines against challenging viruses such as human immunodeficiency virus (HIV), hepatitis C virus, enterovirus A71, and dengue virus. Recent studies demonstrated that applications of this structural information can solve some of the vaccine conundrums. This review focuses on recent advances in structure-based vaccine design, or structural vaccinology, for novel and innovative viral vaccine design.
format Online
Article
Text
id pubmed-6476906
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-64769062019-04-30 Structural Vaccinology for Viral Vaccine Design Anasir, Mohd Ishtiaq Poh, Chit Laa Front Microbiol Microbiology Although vaccines have proven pivotal against arrays of infectious viral diseases, there are still no effective vaccines against many viruses. New structural insights into the viral envelope, protein conformation, and antigenic epitopes can guide the design of novel vaccines against challenging viruses such as human immunodeficiency virus (HIV), hepatitis C virus, enterovirus A71, and dengue virus. Recent studies demonstrated that applications of this structural information can solve some of the vaccine conundrums. This review focuses on recent advances in structure-based vaccine design, or structural vaccinology, for novel and innovative viral vaccine design. Frontiers Media S.A. 2019-04-16 /pmc/articles/PMC6476906/ /pubmed/31040832 http://dx.doi.org/10.3389/fmicb.2019.00738 Text en Copyright © 2019 Anasir and Poh. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Anasir, Mohd Ishtiaq
Poh, Chit Laa
Structural Vaccinology for Viral Vaccine Design
title Structural Vaccinology for Viral Vaccine Design
title_full Structural Vaccinology for Viral Vaccine Design
title_fullStr Structural Vaccinology for Viral Vaccine Design
title_full_unstemmed Structural Vaccinology for Viral Vaccine Design
title_short Structural Vaccinology for Viral Vaccine Design
title_sort structural vaccinology for viral vaccine design
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476906/
https://www.ncbi.nlm.nih.gov/pubmed/31040832
http://dx.doi.org/10.3389/fmicb.2019.00738
work_keys_str_mv AT anasirmohdishtiaq structuralvaccinologyforviralvaccinedesign
AT pohchitlaa structuralvaccinologyforviralvaccinedesign

Ejemplares similares