Myelodysplastic Syndrome-Associated SRSF2 Mutations Cause Splicing Changes by Altering Binding Motif Sequences

Serine/arginine-rich splicing factor 2 (SRSF2) is a member of the SR protein family that is involved in both constitutive and alternative mRNA splicing. Mutations in SRSF2 gene are frequently reported in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). It is imperative to understand...

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Detalles Bibliográficos
Autores principales: Masaki, So, Ikeda, Shun, Hata, Asuka, Shiozawa, Yusuke, Kon, Ayana, Ogawa, Seishi, Suzuki, Kenji, Hakuno, Fumihiko, Takahashi, Shin-Ichiro, Kataoka, Naoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476956/
https://www.ncbi.nlm.nih.gov/pubmed/31040863
http://dx.doi.org/10.3389/fgene.2019.00338

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