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Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5

Multidrug resistance (MDR) in tumors and pathogens remains a major problem in the efficacious treatment of patients by reduction of therapy options and subsequent treatment failure. Various mechanisms are described to be involved in the development of MDR with overexpression of ATP-binding cassette...

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Detalles Bibliográficos
Autores principales:	Sachs, Julia, Döhl, Katja, Weber, Anja, Bonus, Michele, Ehlers, Ferdinand, Fleischer, Edmond, Klinger, Anette, Gohlke, Holger, Pietruszka, Jörg, Schmitt, Lutz, Teusch, Nicole
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476959/ https://www.ncbi.nlm.nih.gov/pubmed/31040786 http://dx.doi.org/10.3389/fphar.2019.00400

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