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The Systemic Administration of the Histamine H(1) Receptor Antagonist/Inverse Agonist Chlorpheniramine to Pregnant Rats Impairs the Development of Nigro-Striatal Dopaminergic Neurons
The dopaminergic and histaminergic systems are the first to appear during the development of the nervous system. Through the activation of H(1) receptors (H(1)Rs), histamine increases neurogenesis of the cortical deep layers, while reducing the dopaminergic phenotype (cells immunoreactive to tyrosin...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476962/ https://www.ncbi.nlm.nih.gov/pubmed/31040765 http://dx.doi.org/10.3389/fnins.2019.00360 |