Trpm2 Ablation Accelerates Protein Aggregation by Impaired ADPR and Autophagic Clearance in the Brain

TRPM2 a cation channel is also known to work as an enzyme that hydrolyzes highly reactive, neurotoxic ADP-ribose (ADPR). Although ADPR is hydrolyzed by NUT9 pyrophosphatase in major organs, the enzyme is defective in the brain. The present study questions the role of TRPM2 in the catabolism of ADPR...

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Detalles Bibliográficos
Autores principales: Jang, Yongwoo, Lee, Byeongjun, Kim, Hyungsup, Jung, Seungmoon, Lee, Sung Hoon, Lee, So-Young, Jeon, Ji Hyun, Kim, In-Beom, Lee, Seo-Ho, Kim, Byung-Ju, Kim, Uh-Hyun, Lee, Yunjong, Kim, Sung Min, Jeon, Daejong, Oh, Uhtaek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477016/
https://www.ncbi.nlm.nih.gov/pubmed/30215158
http://dx.doi.org/10.1007/s12035-018-1309-0

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