Expression of the Neuroblastoma-Associated ALK-F1174L Activating Mutation During Embryogenesis Impairs the Differentiation of Neural Crest Progenitors in Sympathetic Ganglia

Neuroblastoma (NB) is an embryonal malignancy derived from the abnormal differentiation of the sympathetic nervous system. The Anaplastic Lymphoma Kinase (ALK) gene is frequently altered in NB, through copy number alterations and activating mutations, and represents a predisposition in NB-genesis wh...

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Detalles Bibliográficos
Autores principales: Vivancos Stalin, Lucie, Gualandi, Marco, Schulte, Johannes Hubertus, Renella, Raffaele, Shakhova, Olga, Mühlethaler-Mottet, Annick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477091/
https://www.ncbi.nlm.nih.gov/pubmed/31058082
http://dx.doi.org/10.3389/fonc.2019.00275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477091/
https://www.ncbi.nlm.nih.gov/pubmed/31058082
http://dx.doi.org/10.3389/fonc.2019.00275

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