FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates

The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear. Here, we show that disordered residues 326–380 of p62 directly interact...

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Detalles Bibliográficos
Autores principales: Turco, Eleonora, Witt, Marie, Abert, Christine, Bock-Bierbaum, Tobias, Su, Ming-Yuan, Trapannone, Riccardo, Sztacho, Martin, Danieli, Alberto, Shi, Xiaoshan, Zaffagnini, Gabriele, Gamper, Annamaria, Schuschnig, Martina, Fracchiolla, Dorotea, Bernklau, Daniel, Romanov, Julia, Hartl, Markus, Hurley, James H., Daumke, Oliver, Martens, Sascha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477179/
https://www.ncbi.nlm.nih.gov/pubmed/30853400
http://dx.doi.org/10.1016/j.molcel.2019.01.035

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