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Neonatal Encephalopathy: Need for Recognition of Multiple Etiologies for Optimal Management
Neonatal encephalopathy (NE) is associated with high mortality and morbidity. Factors predisposing to NE can be antenatal, perinatal, or a combination of both. Antenatal maternal factors, familial factors, genetic predisposition, hypoxic ischemic encephalopathy, infections, placental abnormalities,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477286/ https://www.ncbi.nlm.nih.gov/pubmed/31058120 http://dx.doi.org/10.3389/fped.2019.00142 |
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author | Aslam, Saima Strickland, Tammy Molloy, Eleanor J. |
author_facet | Aslam, Saima Strickland, Tammy Molloy, Eleanor J. |
author_sort | Aslam, Saima |
collection | PubMed |
description | Neonatal encephalopathy (NE) is associated with high mortality and morbidity. Factors predisposing to NE can be antenatal, perinatal, or a combination of both. Antenatal maternal factors, familial factors, genetic predisposition, hypoxic ischemic encephalopathy, infections, placental abnormalities, thrombophilia, coagulation defects, and metabolic disorders all have been implicated in the pathogenesis of NE. At present, therapeutic hypothermia is the only treatment available, regardless of etiology. Recognizing the etiology of NE involved can also guide investigations such as metabolic and sepsis workups to ensure optimal management. Understanding the etiology of NE may allow the development of targeted adjunctive therapies related to the underlying mechanism and develop preventative strategies. |
format | Online Article Text |
id | pubmed-6477286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64772862019-05-03 Neonatal Encephalopathy: Need for Recognition of Multiple Etiologies for Optimal Management Aslam, Saima Strickland, Tammy Molloy, Eleanor J. Front Pediatr Pediatrics Neonatal encephalopathy (NE) is associated with high mortality and morbidity. Factors predisposing to NE can be antenatal, perinatal, or a combination of both. Antenatal maternal factors, familial factors, genetic predisposition, hypoxic ischemic encephalopathy, infections, placental abnormalities, thrombophilia, coagulation defects, and metabolic disorders all have been implicated in the pathogenesis of NE. At present, therapeutic hypothermia is the only treatment available, regardless of etiology. Recognizing the etiology of NE involved can also guide investigations such as metabolic and sepsis workups to ensure optimal management. Understanding the etiology of NE may allow the development of targeted adjunctive therapies related to the underlying mechanism and develop preventative strategies. Frontiers Media S.A. 2019-04-16 /pmc/articles/PMC6477286/ /pubmed/31058120 http://dx.doi.org/10.3389/fped.2019.00142 Text en Copyright © 2019 Aslam, Strickland and Molloy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Aslam, Saima Strickland, Tammy Molloy, Eleanor J. Neonatal Encephalopathy: Need for Recognition of Multiple Etiologies for Optimal Management |
title | Neonatal Encephalopathy: Need for Recognition of Multiple Etiologies for Optimal Management |
title_full | Neonatal Encephalopathy: Need for Recognition of Multiple Etiologies for Optimal Management |
title_fullStr | Neonatal Encephalopathy: Need for Recognition of Multiple Etiologies for Optimal Management |
title_full_unstemmed | Neonatal Encephalopathy: Need for Recognition of Multiple Etiologies for Optimal Management |
title_short | Neonatal Encephalopathy: Need for Recognition of Multiple Etiologies for Optimal Management |
title_sort | neonatal encephalopathy: need for recognition of multiple etiologies for optimal management |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477286/ https://www.ncbi.nlm.nih.gov/pubmed/31058120 http://dx.doi.org/10.3389/fped.2019.00142 |
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