Cargando…

Is the Outcome of Pulmonary Resections due to Non-Small Cell Lung Cancer in Octogenarian Patients Worse?

Purpose: Lung cancer is one of the major sources of mortality in the elderly. This study was undertaken to assess the early and long-term results of surgical resection in patients older than 70 years of age by comparing the results of patients aged 70–79 years (group 1) with patients older than 80 y...

Descripción completa

Detalles Bibliográficos
Autores principales: Kutluk, Ali Cevat, Akin, Hasan, Ceritoglu, Altan, Kocaturk, Celalettin Ibrahim, Bilen, Salih, Sonmezoglu, Yasar, Karapinar, Kemal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477457/
https://www.ncbi.nlm.nih.gov/pubmed/30542000
http://dx.doi.org/10.5761/atcs.oa.18-00206
_version_ 1783413020213379072
author Kutluk, Ali Cevat
Akin, Hasan
Ceritoglu, Altan
Kocaturk, Celalettin Ibrahim
Bilen, Salih
Sonmezoglu, Yasar
Karapinar, Kemal
author_facet Kutluk, Ali Cevat
Akin, Hasan
Ceritoglu, Altan
Kocaturk, Celalettin Ibrahim
Bilen, Salih
Sonmezoglu, Yasar
Karapinar, Kemal
author_sort Kutluk, Ali Cevat
collection PubMed
description Purpose: Lung cancer is one of the major sources of mortality in the elderly. This study was undertaken to assess the early and long-term results of surgical resection in patients older than 70 years of age by comparing the results of patients aged 70–79 years (group 1) with patients older than 80 years of age (group 2). Methods: Data on patient age, gender, spirometry values, side, size, histology and stage of the tumor, surgical procedures, postoperative complications, Charlson comorbidity scores (CCS), and survival were collected. Results: After 1–2 propensity score matching group 1 (70–79 years) included 84 and group 2 (age over 80) 42 cases. The multivariate analysis showed that CCS was the only significant factor affecting the development of complications (p = 0.003). The overall median and 5-year survival of all patients were 55 months and 42.5%, respectively. Although the survival of the elderly group 2 was higher than the first group, the difference did not reach significance (50 vs. 49 months, respectively). Conclusion: The outcomes of surgery in terms of morbidity and mortality rates do not differ between the two age groups. The safety of pulmonary resections in the elderly group is comparable to patients under 70 years if the comorbidities are appropriately controlled. In addition, surgery provides satisfactory survival rates in both age groups.
format Online
Article
Text
id pubmed-6477457
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery
record_format MEDLINE/PubMed
spelling pubmed-64774572019-04-23 Is the Outcome of Pulmonary Resections due to Non-Small Cell Lung Cancer in Octogenarian Patients Worse? Kutluk, Ali Cevat Akin, Hasan Ceritoglu, Altan Kocaturk, Celalettin Ibrahim Bilen, Salih Sonmezoglu, Yasar Karapinar, Kemal Ann Thorac Cardiovasc Surg Original Article Purpose: Lung cancer is one of the major sources of mortality in the elderly. This study was undertaken to assess the early and long-term results of surgical resection in patients older than 70 years of age by comparing the results of patients aged 70–79 years (group 1) with patients older than 80 years of age (group 2). Methods: Data on patient age, gender, spirometry values, side, size, histology and stage of the tumor, surgical procedures, postoperative complications, Charlson comorbidity scores (CCS), and survival were collected. Results: After 1–2 propensity score matching group 1 (70–79 years) included 84 and group 2 (age over 80) 42 cases. The multivariate analysis showed that CCS was the only significant factor affecting the development of complications (p = 0.003). The overall median and 5-year survival of all patients were 55 months and 42.5%, respectively. Although the survival of the elderly group 2 was higher than the first group, the difference did not reach significance (50 vs. 49 months, respectively). Conclusion: The outcomes of surgery in terms of morbidity and mortality rates do not differ between the two age groups. The safety of pulmonary resections in the elderly group is comparable to patients under 70 years if the comorbidities are appropriately controlled. In addition, surgery provides satisfactory survival rates in both age groups. The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery 2018-12-11 2019 /pmc/articles/PMC6477457/ /pubmed/30542000 http://dx.doi.org/10.5761/atcs.oa.18-00206 Text en ©2019 Annals of Thoracic and Cardiovascular Surgery http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NonDerivatives International License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Article
Kutluk, Ali Cevat
Akin, Hasan
Ceritoglu, Altan
Kocaturk, Celalettin Ibrahim
Bilen, Salih
Sonmezoglu, Yasar
Karapinar, Kemal
Is the Outcome of Pulmonary Resections due to Non-Small Cell Lung Cancer in Octogenarian Patients Worse?
title Is the Outcome of Pulmonary Resections due to Non-Small Cell Lung Cancer in Octogenarian Patients Worse?
title_full Is the Outcome of Pulmonary Resections due to Non-Small Cell Lung Cancer in Octogenarian Patients Worse?
title_fullStr Is the Outcome of Pulmonary Resections due to Non-Small Cell Lung Cancer in Octogenarian Patients Worse?
title_full_unstemmed Is the Outcome of Pulmonary Resections due to Non-Small Cell Lung Cancer in Octogenarian Patients Worse?
title_short Is the Outcome of Pulmonary Resections due to Non-Small Cell Lung Cancer in Octogenarian Patients Worse?
title_sort is the outcome of pulmonary resections due to non-small cell lung cancer in octogenarian patients worse?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477457/
https://www.ncbi.nlm.nih.gov/pubmed/30542000
http://dx.doi.org/10.5761/atcs.oa.18-00206
work_keys_str_mv AT kutlukalicevat istheoutcomeofpulmonaryresectionsduetononsmallcelllungcancerinoctogenarianpatientsworse
AT akinhasan istheoutcomeofpulmonaryresectionsduetononsmallcelllungcancerinoctogenarianpatientsworse
AT ceritoglualtan istheoutcomeofpulmonaryresectionsduetononsmallcelllungcancerinoctogenarianpatientsworse
AT kocaturkcelalettinibrahim istheoutcomeofpulmonaryresectionsduetononsmallcelllungcancerinoctogenarianpatientsworse
AT bilensalih istheoutcomeofpulmonaryresectionsduetononsmallcelllungcancerinoctogenarianpatientsworse
AT sonmezogluyasar istheoutcomeofpulmonaryresectionsduetononsmallcelllungcancerinoctogenarianpatientsworse
AT karapinarkemal istheoutcomeofpulmonaryresectionsduetononsmallcelllungcancerinoctogenarianpatientsworse