Cholesterol crystals promote endothelial cell and monocyte interactions via H(2)O(2)-mediated PP2A inhibition, NFκB activation and ICAM1 and VCAM1 expression

In the present study, we show that cholesterol crystals induce NFκB activation, and ICAM1 and VCAM1 expression via xanthine oxidase-mediated H(2)O(2) production and PP2A inhibition in influencing endothelial cell and monocyte interactions and all these adverse effects of cholesterol crystals could b...

Descripción completa

Detalles Bibliográficos
Autores principales: Pichavaram, Prahalathan, Mani, Arul M., Singh, Nikhlesh K., Rao, Gadiparthi N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477634/
https://www.ncbi.nlm.nih.gov/pubmed/31022672
http://dx.doi.org/10.1016/j.redox.2019.101180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477634/
https://www.ncbi.nlm.nih.gov/pubmed/31022672
http://dx.doi.org/10.1016/j.redox.2019.101180

Ejemplares similares