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PGE2 and Poloxamer Synperonic F108 Enhance Transduction of Human HSPCs with a β-Globin Lentiviral Vector

Lentiviral vector (LV)-based hematopoietic stem and progenitor cell (HSPC) gene therapy is becoming a promising alternative to allogeneic stem cell transplantation for curing genetic diseases. Clinical trials are currently underway to treat sickle cell disease using LVs expressing designed anti-sick...

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Detalles Bibliográficos
Autores principales:	Masiuk, Katelyn E., Zhang, Ruixue, Osborne, Kyle, Hollis, Roger P., Campo-Fernandez, Beatriz, Kohn, Donald B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477655/ https://www.ncbi.nlm.nih.gov/pubmed/31024981 http://dx.doi.org/10.1016/j.omtm.2019.03.005

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