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Combining directed evolution of pathway enzymes and dynamic pathway regulation using a quorum-sensing circuit to improve the production of 4-hydroxyphenylacetic acid in Escherichia coli

BACKGROUND: 4-Hydroxyphenylacetic acid (4HPAA) is an important building block for synthesizing drugs, agrochemicals, biochemicals, etc. 4HPAA is currently produced exclusively via petrochemical processes and the process is environmentally unfriendly and unsustainable. Microbial cell factory would be...

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Detalles Bibliográficos
Autores principales:	Shen, Yu-Ping, Fong, Lai San, Yan, Zhi-Bo, Liu, Jian-Zhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477704/ https://www.ncbi.nlm.nih.gov/pubmed/31044007 http://dx.doi.org/10.1186/s13068-019-1438-3

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