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Association between statin treatment and new-onset diabetes mellitus: a population based case–control study

BACKGROUND: Several studies suggest that statin may increase the risk of new-onset diabetes mellitus (NODM). This study aimed to evaluate the association between the duration and recent use of statin, and the risk of NODM, based on population-based data sets. METHODS: We used the South Korean Nation...

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Autores principales: Kim, Dong-Won, Kim, Do-Hoon, Park, Joo-Hyun, Choi, Moonyoung, Kim, Shinhye, Kim, Hyonchong, Seul, Da-eun, Park, Soo-Gyeong, Jung, Jin-Hyung, Han, Kyungdo, Park, Yong-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477721/
https://www.ncbi.nlm.nih.gov/pubmed/31044020
http://dx.doi.org/10.1186/s13098-019-0427-9
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author Kim, Dong-Won
Kim, Do-Hoon
Park, Joo-Hyun
Choi, Moonyoung
Kim, Shinhye
Kim, Hyonchong
Seul, Da-eun
Park, Soo-Gyeong
Jung, Jin-Hyung
Han, Kyungdo
Park, Yong-Gyu
author_facet Kim, Dong-Won
Kim, Do-Hoon
Park, Joo-Hyun
Choi, Moonyoung
Kim, Shinhye
Kim, Hyonchong
Seul, Da-eun
Park, Soo-Gyeong
Jung, Jin-Hyung
Han, Kyungdo
Park, Yong-Gyu
author_sort Kim, Dong-Won
collection PubMed
description BACKGROUND: Several studies suggest that statin may increase the risk of new-onset diabetes mellitus (NODM). This study aimed to evaluate the association between the duration and recent use of statin, and the risk of NODM, based on population-based data sets. METHODS: We used the South Korean National Health Insurance Service National Sample Cohort database for this nationwide case–control study. Of the 1 million participants, 6417 participants with NODM in 2012–2013 and 32,085 controls without diabetes (1:5 propensity score matched with age, sex, index year, and year of diabetes diagnosis) were included. In these patients, we examined the statin prescription record for 3 years preceding the outcome. We used conditional logistic regression to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: After adjustment of covariates, there were no significant differences in the risk of NODM when analyzed according to cumulative use days. The risk of NODM was increased only in the short-term and recent user group (OR 1.48, 95% CI 1.21 to 1.82) whose cumulative prescription days are less than 6 months and whose last prescription is within 6 months of diagnosis. CONCLUSIONS: The risk of NODM was not associated with an increase in the cumulative duration of statin use or with non-recent use. Only recent short-term use of statin was associated with an increased risk of NODM. Diabetes screening are warranted during initial statin therapy.
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spelling pubmed-64777212019-05-01 Association between statin treatment and new-onset diabetes mellitus: a population based case–control study Kim, Dong-Won Kim, Do-Hoon Park, Joo-Hyun Choi, Moonyoung Kim, Shinhye Kim, Hyonchong Seul, Da-eun Park, Soo-Gyeong Jung, Jin-Hyung Han, Kyungdo Park, Yong-Gyu Diabetol Metab Syndr Research BACKGROUND: Several studies suggest that statin may increase the risk of new-onset diabetes mellitus (NODM). This study aimed to evaluate the association between the duration and recent use of statin, and the risk of NODM, based on population-based data sets. METHODS: We used the South Korean National Health Insurance Service National Sample Cohort database for this nationwide case–control study. Of the 1 million participants, 6417 participants with NODM in 2012–2013 and 32,085 controls without diabetes (1:5 propensity score matched with age, sex, index year, and year of diabetes diagnosis) were included. In these patients, we examined the statin prescription record for 3 years preceding the outcome. We used conditional logistic regression to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: After adjustment of covariates, there were no significant differences in the risk of NODM when analyzed according to cumulative use days. The risk of NODM was increased only in the short-term and recent user group (OR 1.48, 95% CI 1.21 to 1.82) whose cumulative prescription days are less than 6 months and whose last prescription is within 6 months of diagnosis. CONCLUSIONS: The risk of NODM was not associated with an increase in the cumulative duration of statin use or with non-recent use. Only recent short-term use of statin was associated with an increased risk of NODM. Diabetes screening are warranted during initial statin therapy. BioMed Central 2019-04-22 /pmc/articles/PMC6477721/ /pubmed/31044020 http://dx.doi.org/10.1186/s13098-019-0427-9 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Kim, Dong-Won
Kim, Do-Hoon
Park, Joo-Hyun
Choi, Moonyoung
Kim, Shinhye
Kim, Hyonchong
Seul, Da-eun
Park, Soo-Gyeong
Jung, Jin-Hyung
Han, Kyungdo
Park, Yong-Gyu
Association between statin treatment and new-onset diabetes mellitus: a population based case–control study
title Association between statin treatment and new-onset diabetes mellitus: a population based case–control study
title_full Association between statin treatment and new-onset diabetes mellitus: a population based case–control study
title_fullStr Association between statin treatment and new-onset diabetes mellitus: a population based case–control study
title_full_unstemmed Association between statin treatment and new-onset diabetes mellitus: a population based case–control study
title_short Association between statin treatment and new-onset diabetes mellitus: a population based case–control study
title_sort association between statin treatment and new-onset diabetes mellitus: a population based case–control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477721/
https://www.ncbi.nlm.nih.gov/pubmed/31044020
http://dx.doi.org/10.1186/s13098-019-0427-9
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