Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients

BACKGROUND: The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking antigen-specific CD8(+), but not CD4(+), T-cell responses that deliver anti-tumor immunity without autoimmunity in mice. Here, the cancer vaccine Ad5-GUCY2C-PADRE was evaluated in a first-in-man phase I clinica...

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Detalles Bibliográficos
Autores principales: Snook, Adam E., Baybutt, Trevor R., Xiang, Bo, Abraham, Tara S., Flickinger, John C., Hyslop, Terry, Zhan, Tingting, Kraft, Walter K., Sato, Takami, Waldman, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477737/
https://www.ncbi.nlm.nih.gov/pubmed/31010434
http://dx.doi.org/10.1186/s40425-019-0576-2

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