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Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

OBJECTIVE: We recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity by inducing a M2 to M1 phenotype switch in monocyte/macrophage models. In the present study we investigated the potential role of protein kinases in mediating this effect. RESULTS: MBZ pot...

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Detalles Bibliográficos
Autores principales:	Blom, Kristin, Rubin, Jenny, Berglund, Malin, Jarvius, Malin, Lenhammar, Lena, Parrow, Vendela, Andersson, Claes, Loskog, Angelica, Fryknäs, Mårten, Nygren, Peter, Larsson, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Note
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477744/ https://www.ncbi.nlm.nih.gov/pubmed/31010428 http://dx.doi.org/10.1186/s13104-019-4273-5

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