Cargando…

Schizophrenia and Corollary Discharge: A Neuroscientific Overview and Translational Implications

Corollary discharge mechanism refers to the suppression of sensory consequences of self-generated actions; a process that serves to distinguish between self and non-self based on discrimination of origination of action. It explains, say for example, why we cannot tickle ourselves. This review discus...

Descripción completa

Detalles Bibliográficos
Autores principales: Parlikar, Rujuta, Bose, Anushree, Venkatasubramanian, Ganesan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478093/
https://www.ncbi.nlm.nih.gov/pubmed/30905117
http://dx.doi.org/10.9758/cpn.2019.17.2.170
_version_ 1783413127408254976
author Parlikar, Rujuta
Bose, Anushree
Venkatasubramanian, Ganesan
author_facet Parlikar, Rujuta
Bose, Anushree
Venkatasubramanian, Ganesan
author_sort Parlikar, Rujuta
collection PubMed
description Corollary discharge mechanism refers to the suppression of sensory consequences of self-generated actions; a process that serves to distinguish between self and non-self based on discrimination of origination of action. It explains, say for example, why we cannot tickle ourselves. This review discusses how corollary discharge model is an essential neural integration mechanism central to the motor functioning of animal kingdom. In this article, research conducted in the field of corollary discharge has been reviewed to understand the neuroanatomical and neurophysiological basis of corollary discharge and gain insight into the biochemical basis of its dysfunction. This review article also explores the role of corollary discharge and its dysfunction in the presentation of symptoms of schizophrenia, discussing the findings from corollary discharge studies on schizophrenia population. Lastly, the link between schizophrenia psychopathology and corollary discharge dysfunction has been highlighted, and an attempt has been made to establish a case for correction of corollary discharge deficit in schizophrenia through neuromodulation.
format Online
Article
Text
id pubmed-6478093
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Korean College of Neuropsychopharmacology
record_format MEDLINE/PubMed
spelling pubmed-64780932019-05-07 Schizophrenia and Corollary Discharge: A Neuroscientific Overview and Translational Implications Parlikar, Rujuta Bose, Anushree Venkatasubramanian, Ganesan Clin Psychopharmacol Neurosci Review Corollary discharge mechanism refers to the suppression of sensory consequences of self-generated actions; a process that serves to distinguish between self and non-self based on discrimination of origination of action. It explains, say for example, why we cannot tickle ourselves. This review discusses how corollary discharge model is an essential neural integration mechanism central to the motor functioning of animal kingdom. In this article, research conducted in the field of corollary discharge has been reviewed to understand the neuroanatomical and neurophysiological basis of corollary discharge and gain insight into the biochemical basis of its dysfunction. This review article also explores the role of corollary discharge and its dysfunction in the presentation of symptoms of schizophrenia, discussing the findings from corollary discharge studies on schizophrenia population. Lastly, the link between schizophrenia psychopathology and corollary discharge dysfunction has been highlighted, and an attempt has been made to establish a case for correction of corollary discharge deficit in schizophrenia through neuromodulation. Korean College of Neuropsychopharmacology 2019-03 2019-04-30 /pmc/articles/PMC6478093/ /pubmed/30905117 http://dx.doi.org/10.9758/cpn.2019.17.2.170 Text en Copyright © 2019, Korean College of Neuropsychopharmacology This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Parlikar, Rujuta
Bose, Anushree
Venkatasubramanian, Ganesan
Schizophrenia and Corollary Discharge: A Neuroscientific Overview and Translational Implications
title Schizophrenia and Corollary Discharge: A Neuroscientific Overview and Translational Implications
title_full Schizophrenia and Corollary Discharge: A Neuroscientific Overview and Translational Implications
title_fullStr Schizophrenia and Corollary Discharge: A Neuroscientific Overview and Translational Implications
title_full_unstemmed Schizophrenia and Corollary Discharge: A Neuroscientific Overview and Translational Implications
title_short Schizophrenia and Corollary Discharge: A Neuroscientific Overview and Translational Implications
title_sort schizophrenia and corollary discharge: a neuroscientific overview and translational implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478093/
https://www.ncbi.nlm.nih.gov/pubmed/30905117
http://dx.doi.org/10.9758/cpn.2019.17.2.170
work_keys_str_mv AT parlikarrujuta schizophreniaandcorollarydischargeaneuroscientificoverviewandtranslationalimplications
AT boseanushree schizophreniaandcorollarydischargeaneuroscientificoverviewandtranslationalimplications
AT venkatasubramanianganesan schizophreniaandcorollarydischargeaneuroscientificoverviewandtranslationalimplications