Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo

How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca(2+)](i) in developing oligodendrocytes in vivo, and that myelin sheath elongation is promoted by a high frequency of [Ca(2+)](i) transients and prevented by [Ca(2+)](i)-buffering. S...

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Detalles Bibliográficos
Autores principales: Krasnow, Anna M., Ford, Marc C., Valdivia, Leonardo E., Wilson, Stephen W., Attwell, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478117/
https://www.ncbi.nlm.nih.gov/pubmed/29230052
http://dx.doi.org/10.1038/s41593-017-0031-y
Descripción
Sumario:How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca(2+)](i) in developing oligodendrocytes in vivo, and that myelin sheath elongation is promoted by a high frequency of [Ca(2+)](i) transients and prevented by [Ca(2+)](i)-buffering. Sheath elongation occurs ~1 hour after [Ca(2+)](i) elevation. Sheath shortening is associated with a low frequency of [Ca(2+)](i) transients but with longer duration [Ca(2+)](i) bursts. Thus, [Ca(2+)](i) controls myelin sheath development.

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