Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo

How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca(2+)](i) in developing oligodendrocytes in vivo, and that myelin sheath elongation is promoted by a high frequency of [Ca(2+)](i) transients and prevented by [Ca(2+)](i)-buffering. S...

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Autores principales: Krasnow, Anna M., Ford, Marc C., Valdivia, Leonardo E., Wilson, Stephen W., Attwell, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478117/
https://www.ncbi.nlm.nih.gov/pubmed/29230052
http://dx.doi.org/10.1038/s41593-017-0031-y
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author Krasnow, Anna M.
Ford, Marc C.
Valdivia, Leonardo E.
Wilson, Stephen W.
Attwell, David
author_facet Krasnow, Anna M.
Ford, Marc C.
Valdivia, Leonardo E.
Wilson, Stephen W.
Attwell, David
author_sort Krasnow, Anna M.
collection PubMed
description How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca(2+)](i) in developing oligodendrocytes in vivo, and that myelin sheath elongation is promoted by a high frequency of [Ca(2+)](i) transients and prevented by [Ca(2+)](i)-buffering. Sheath elongation occurs ~1 hour after [Ca(2+)](i) elevation. Sheath shortening is associated with a low frequency of [Ca(2+)](i) transients but with longer duration [Ca(2+)](i) bursts. Thus, [Ca(2+)](i) controls myelin sheath development.
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spelling pubmed-64781172019-04-23 Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo Krasnow, Anna M. Ford, Marc C. Valdivia, Leonardo E. Wilson, Stephen W. Attwell, David Nat Neurosci Article How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca(2+)](i) in developing oligodendrocytes in vivo, and that myelin sheath elongation is promoted by a high frequency of [Ca(2+)](i) transients and prevented by [Ca(2+)](i)-buffering. Sheath elongation occurs ~1 hour after [Ca(2+)](i) elevation. Sheath shortening is associated with a low frequency of [Ca(2+)](i) transients but with longer duration [Ca(2+)](i) bursts. Thus, [Ca(2+)](i) controls myelin sheath development. 2017-12-11 2018-01 /pmc/articles/PMC6478117/ /pubmed/29230052 http://dx.doi.org/10.1038/s41593-017-0031-y Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Krasnow, Anna M.
Ford, Marc C.
Valdivia, Leonardo E.
Wilson, Stephen W.
Attwell, David
Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
title Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
title_full Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
title_fullStr Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
title_full_unstemmed Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
title_short Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
title_sort regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478117/
https://www.ncbi.nlm.nih.gov/pubmed/29230052
http://dx.doi.org/10.1038/s41593-017-0031-y
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