Serologic Prevalence of Ebola Virus in Equatorial Africa

We conducted a serologic survey of 2,430 serum samples collected during 1997–2012 for various studies to determine the prevalence of the hemorrhagic fever virus Ebola virus (EBOV) in equatorial Africa. We screened serum samples for neutralizing antibodies by using a pseudotype microneutralization as...

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Detalles Bibliográficos
Autores principales: Steffen, Imke, Lu, Kai, Yamamoto, Lauren K., Hoff, Nicole A., Mulembakani, Prime, Wemakoy, Emile O., Muyembe-Tamfum, Jean-Jacques, Ndembi, Nicaise, Brennan, Catherine A., Hackett, John, Stramer, Susan L., Switzer, William M., Saragosti, Sentob, Mbensa, Guy O., Laperche, Syria, Rimoin, Anne W., Simmons, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478206/
https://www.ncbi.nlm.nih.gov/pubmed/31002071
http://dx.doi.org/10.3201/eid2505.180115
Descripción
Sumario:We conducted a serologic survey of 2,430 serum samples collected during 1997–2012 for various studies to determine the prevalence of the hemorrhagic fever virus Ebola virus (EBOV) in equatorial Africa. We screened serum samples for neutralizing antibodies by using a pseudotype microneutralization assay and a newly developed luciferase immunoprecipitation system assay. Specimens seroreactive for EBOV were confirmed by using an ELISA. Our results suggest a serologic prevalence of 2%–3.5% in the Republic of the Congo and the Democratic Republic of the Congo, which have reported outbreaks of infection with EBOV. In addition we detected a seroprevalence of 1.3% in southern Cameroon, which indicated a low risk for exposure in this region.

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