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Infectious Dose of African Swine Fever Virus When Consumed Naturally in Liquid or Feed

African swine fever virus (ASFV) is a contagious, rapidly spreading, transboundary animal disease and a major threat to pork production globally. Although plant-based feed has been identified as a potential route for virus introduction onto swine farms, little is known about the risks for ASFV trans...

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Autores principales: Niederwerder, Megan C., Stoian, Ana M.M., Rowland, Raymond R.R., Dritz, Steve S., Petrovan, Vlad, Constance, Laura A., Gebhardt, Jordan T., Olcha, Matthew, Jones, Cassandra K., Woodworth, Jason C., Fang, Ying, Liang, Jia, Hefley, Trevor J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478231/
https://www.ncbi.nlm.nih.gov/pubmed/30761988
http://dx.doi.org/10.3201/eid2505.181495
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author Niederwerder, Megan C.
Stoian, Ana M.M.
Rowland, Raymond R.R.
Dritz, Steve S.
Petrovan, Vlad
Constance, Laura A.
Gebhardt, Jordan T.
Olcha, Matthew
Jones, Cassandra K.
Woodworth, Jason C.
Fang, Ying
Liang, Jia
Hefley, Trevor J.
author_facet Niederwerder, Megan C.
Stoian, Ana M.M.
Rowland, Raymond R.R.
Dritz, Steve S.
Petrovan, Vlad
Constance, Laura A.
Gebhardt, Jordan T.
Olcha, Matthew
Jones, Cassandra K.
Woodworth, Jason C.
Fang, Ying
Liang, Jia
Hefley, Trevor J.
author_sort Niederwerder, Megan C.
collection PubMed
description African swine fever virus (ASFV) is a contagious, rapidly spreading, transboundary animal disease and a major threat to pork production globally. Although plant-based feed has been identified as a potential route for virus introduction onto swine farms, little is known about the risks for ASFV transmission in feed. We aimed to determine the minimum and median infectious doses of the Georgia 2007 strain of ASFV through oral exposure during natural drinking and feeding behaviors. The minimum infectious dose of ASFV in liquid was 10(0) 50% tissue culture infectious dose (TCID(50)), compared with 10(4) TCID(50) in feed. The median infectious dose was 10(1.0) TCID(50) for liquid and 10(6.8) TCID(50) for feed. Our findings demonstrate that ASFV Georgia 2007 can easily be transmitted orally, although higher doses are required for infection in plant-based feed. These data provide important information that can be incorporated into risk models for ASFV transmission.
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spelling pubmed-64782312019-05-08 Infectious Dose of African Swine Fever Virus When Consumed Naturally in Liquid or Feed Niederwerder, Megan C. Stoian, Ana M.M. Rowland, Raymond R.R. Dritz, Steve S. Petrovan, Vlad Constance, Laura A. Gebhardt, Jordan T. Olcha, Matthew Jones, Cassandra K. Woodworth, Jason C. Fang, Ying Liang, Jia Hefley, Trevor J. Emerg Infect Dis Research African swine fever virus (ASFV) is a contagious, rapidly spreading, transboundary animal disease and a major threat to pork production globally. Although plant-based feed has been identified as a potential route for virus introduction onto swine farms, little is known about the risks for ASFV transmission in feed. We aimed to determine the minimum and median infectious doses of the Georgia 2007 strain of ASFV through oral exposure during natural drinking and feeding behaviors. The minimum infectious dose of ASFV in liquid was 10(0) 50% tissue culture infectious dose (TCID(50)), compared with 10(4) TCID(50) in feed. The median infectious dose was 10(1.0) TCID(50) for liquid and 10(6.8) TCID(50) for feed. Our findings demonstrate that ASFV Georgia 2007 can easily be transmitted orally, although higher doses are required for infection in plant-based feed. These data provide important information that can be incorporated into risk models for ASFV transmission. Centers for Disease Control and Prevention 2019-05 /pmc/articles/PMC6478231/ /pubmed/30761988 http://dx.doi.org/10.3201/eid2505.181495 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Niederwerder, Megan C.
Stoian, Ana M.M.
Rowland, Raymond R.R.
Dritz, Steve S.
Petrovan, Vlad
Constance, Laura A.
Gebhardt, Jordan T.
Olcha, Matthew
Jones, Cassandra K.
Woodworth, Jason C.
Fang, Ying
Liang, Jia
Hefley, Trevor J.
Infectious Dose of African Swine Fever Virus When Consumed Naturally in Liquid or Feed
title Infectious Dose of African Swine Fever Virus When Consumed Naturally in Liquid or Feed
title_full Infectious Dose of African Swine Fever Virus When Consumed Naturally in Liquid or Feed
title_fullStr Infectious Dose of African Swine Fever Virus When Consumed Naturally in Liquid or Feed
title_full_unstemmed Infectious Dose of African Swine Fever Virus When Consumed Naturally in Liquid or Feed
title_short Infectious Dose of African Swine Fever Virus When Consumed Naturally in Liquid or Feed
title_sort infectious dose of african swine fever virus when consumed naturally in liquid or feed
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478231/
https://www.ncbi.nlm.nih.gov/pubmed/30761988
http://dx.doi.org/10.3201/eid2505.181495
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