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Effects of hydrogen-rich water in a rat model of polycystic kidney disease
Various factors are considered to be mechanisms of the increase in the sizes of cysts in patients with polycystic kidney disease. Vasopressin is one of the causes, and drinking large volumes of water shows an effect of suppressing an increase in cysts. On the other hand, it is known that hydrogen-ri...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478309/ https://www.ncbi.nlm.nih.gov/pubmed/31013316 http://dx.doi.org/10.1371/journal.pone.0215766 |
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author | Yamasaki, Masatora Miyazono, Motoaki Yoshihara, Maki Suenaga, Atsuhiko Mizuta, Masato Fukuda, Makoto Rikitake, Shuichi Ikeda, Yuji |
author_facet | Yamasaki, Masatora Miyazono, Motoaki Yoshihara, Maki Suenaga, Atsuhiko Mizuta, Masato Fukuda, Makoto Rikitake, Shuichi Ikeda, Yuji |
author_sort | Yamasaki, Masatora |
collection | PubMed |
description | Various factors are considered to be mechanisms of the increase in the sizes of cysts in patients with polycystic kidney disease. Vasopressin is one of the causes, and drinking large volumes of water shows an effect of suppressing an increase in cysts. On the other hand, it is known that hydrogen-rich water reduces oxidative stress and has a good effect on kidney injury. We examined whether drinking large volumes of hydrogen-rich water affected the increase in the sizes of cysts. Forty 5-week-old PCK rats were randomly assigned to four groups: C(Control), purified water; W(Water), water with sugar; H(Hydrogen), hydrogen-rich water; WH(Water+Hydrogen), hydrogen-rich water with sugar. They consumed water from 5 to 15 weeks of age. The intake of water in the groups in which sugar was added to the water (W, WH) significantly increased in comparison to C, but there was no significant change in the serum Creatinine concentration. The kidney weight per body weight in W was significantly decreased in comparison to C. The kidney weights in H and WH were significantly increased in comparison to W. There were no significant differences in the ratio of the cross-sectional area of the cysts to the whole area among the groups. This experiment showed that the effect of drinking large volumes of hydrogen-rich water was not significantly different from that of normal water, in terms of preventing an increase in the size of cysts in PCK rats. However, some papers acknowledge the influence of hydrogen water. Significant differences might become obvious if we change aspects such as the administration method or administration period. |
format | Online Article Text |
id | pubmed-6478309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-64783092019-05-07 Effects of hydrogen-rich water in a rat model of polycystic kidney disease Yamasaki, Masatora Miyazono, Motoaki Yoshihara, Maki Suenaga, Atsuhiko Mizuta, Masato Fukuda, Makoto Rikitake, Shuichi Ikeda, Yuji PLoS One Research Article Various factors are considered to be mechanisms of the increase in the sizes of cysts in patients with polycystic kidney disease. Vasopressin is one of the causes, and drinking large volumes of water shows an effect of suppressing an increase in cysts. On the other hand, it is known that hydrogen-rich water reduces oxidative stress and has a good effect on kidney injury. We examined whether drinking large volumes of hydrogen-rich water affected the increase in the sizes of cysts. Forty 5-week-old PCK rats were randomly assigned to four groups: C(Control), purified water; W(Water), water with sugar; H(Hydrogen), hydrogen-rich water; WH(Water+Hydrogen), hydrogen-rich water with sugar. They consumed water from 5 to 15 weeks of age. The intake of water in the groups in which sugar was added to the water (W, WH) significantly increased in comparison to C, but there was no significant change in the serum Creatinine concentration. The kidney weight per body weight in W was significantly decreased in comparison to C. The kidney weights in H and WH were significantly increased in comparison to W. There were no significant differences in the ratio of the cross-sectional area of the cysts to the whole area among the groups. This experiment showed that the effect of drinking large volumes of hydrogen-rich water was not significantly different from that of normal water, in terms of preventing an increase in the size of cysts in PCK rats. However, some papers acknowledge the influence of hydrogen water. Significant differences might become obvious if we change aspects such as the administration method or administration period. Public Library of Science 2019-04-23 /pmc/articles/PMC6478309/ /pubmed/31013316 http://dx.doi.org/10.1371/journal.pone.0215766 Text en © 2019 Yamasaki et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Yamasaki, Masatora Miyazono, Motoaki Yoshihara, Maki Suenaga, Atsuhiko Mizuta, Masato Fukuda, Makoto Rikitake, Shuichi Ikeda, Yuji Effects of hydrogen-rich water in a rat model of polycystic kidney disease |
title | Effects of hydrogen-rich water in a rat model of polycystic kidney disease |
title_full | Effects of hydrogen-rich water in a rat model of polycystic kidney disease |
title_fullStr | Effects of hydrogen-rich water in a rat model of polycystic kidney disease |
title_full_unstemmed | Effects of hydrogen-rich water in a rat model of polycystic kidney disease |
title_short | Effects of hydrogen-rich water in a rat model of polycystic kidney disease |
title_sort | effects of hydrogen-rich water in a rat model of polycystic kidney disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478309/ https://www.ncbi.nlm.nih.gov/pubmed/31013316 http://dx.doi.org/10.1371/journal.pone.0215766 |
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