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Effects of hydrogen-rich water in a rat model of polycystic kidney disease

Various factors are considered to be mechanisms of the increase in the sizes of cysts in patients with polycystic kidney disease. Vasopressin is one of the causes, and drinking large volumes of water shows an effect of suppressing an increase in cysts. On the other hand, it is known that hydrogen-ri...

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Autores principales: Yamasaki, Masatora, Miyazono, Motoaki, Yoshihara, Maki, Suenaga, Atsuhiko, Mizuta, Masato, Fukuda, Makoto, Rikitake, Shuichi, Ikeda, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478309/
https://www.ncbi.nlm.nih.gov/pubmed/31013316
http://dx.doi.org/10.1371/journal.pone.0215766
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author Yamasaki, Masatora
Miyazono, Motoaki
Yoshihara, Maki
Suenaga, Atsuhiko
Mizuta, Masato
Fukuda, Makoto
Rikitake, Shuichi
Ikeda, Yuji
author_facet Yamasaki, Masatora
Miyazono, Motoaki
Yoshihara, Maki
Suenaga, Atsuhiko
Mizuta, Masato
Fukuda, Makoto
Rikitake, Shuichi
Ikeda, Yuji
author_sort Yamasaki, Masatora
collection PubMed
description Various factors are considered to be mechanisms of the increase in the sizes of cysts in patients with polycystic kidney disease. Vasopressin is one of the causes, and drinking large volumes of water shows an effect of suppressing an increase in cysts. On the other hand, it is known that hydrogen-rich water reduces oxidative stress and has a good effect on kidney injury. We examined whether drinking large volumes of hydrogen-rich water affected the increase in the sizes of cysts. Forty 5-week-old PCK rats were randomly assigned to four groups: C(Control), purified water; W(Water), water with sugar; H(Hydrogen), hydrogen-rich water; WH(Water+Hydrogen), hydrogen-rich water with sugar. They consumed water from 5 to 15 weeks of age. The intake of water in the groups in which sugar was added to the water (W, WH) significantly increased in comparison to C, but there was no significant change in the serum Creatinine concentration. The kidney weight per body weight in W was significantly decreased in comparison to C. The kidney weights in H and WH were significantly increased in comparison to W. There were no significant differences in the ratio of the cross-sectional area of the cysts to the whole area among the groups. This experiment showed that the effect of drinking large volumes of hydrogen-rich water was not significantly different from that of normal water, in terms of preventing an increase in the size of cysts in PCK rats. However, some papers acknowledge the influence of hydrogen water. Significant differences might become obvious if we change aspects such as the administration method or administration period.
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spelling pubmed-64783092019-05-07 Effects of hydrogen-rich water in a rat model of polycystic kidney disease Yamasaki, Masatora Miyazono, Motoaki Yoshihara, Maki Suenaga, Atsuhiko Mizuta, Masato Fukuda, Makoto Rikitake, Shuichi Ikeda, Yuji PLoS One Research Article Various factors are considered to be mechanisms of the increase in the sizes of cysts in patients with polycystic kidney disease. Vasopressin is one of the causes, and drinking large volumes of water shows an effect of suppressing an increase in cysts. On the other hand, it is known that hydrogen-rich water reduces oxidative stress and has a good effect on kidney injury. We examined whether drinking large volumes of hydrogen-rich water affected the increase in the sizes of cysts. Forty 5-week-old PCK rats were randomly assigned to four groups: C(Control), purified water; W(Water), water with sugar; H(Hydrogen), hydrogen-rich water; WH(Water+Hydrogen), hydrogen-rich water with sugar. They consumed water from 5 to 15 weeks of age. The intake of water in the groups in which sugar was added to the water (W, WH) significantly increased in comparison to C, but there was no significant change in the serum Creatinine concentration. The kidney weight per body weight in W was significantly decreased in comparison to C. The kidney weights in H and WH were significantly increased in comparison to W. There were no significant differences in the ratio of the cross-sectional area of the cysts to the whole area among the groups. This experiment showed that the effect of drinking large volumes of hydrogen-rich water was not significantly different from that of normal water, in terms of preventing an increase in the size of cysts in PCK rats. However, some papers acknowledge the influence of hydrogen water. Significant differences might become obvious if we change aspects such as the administration method or administration period. Public Library of Science 2019-04-23 /pmc/articles/PMC6478309/ /pubmed/31013316 http://dx.doi.org/10.1371/journal.pone.0215766 Text en © 2019 Yamasaki et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yamasaki, Masatora
Miyazono, Motoaki
Yoshihara, Maki
Suenaga, Atsuhiko
Mizuta, Masato
Fukuda, Makoto
Rikitake, Shuichi
Ikeda, Yuji
Effects of hydrogen-rich water in a rat model of polycystic kidney disease
title Effects of hydrogen-rich water in a rat model of polycystic kidney disease
title_full Effects of hydrogen-rich water in a rat model of polycystic kidney disease
title_fullStr Effects of hydrogen-rich water in a rat model of polycystic kidney disease
title_full_unstemmed Effects of hydrogen-rich water in a rat model of polycystic kidney disease
title_short Effects of hydrogen-rich water in a rat model of polycystic kidney disease
title_sort effects of hydrogen-rich water in a rat model of polycystic kidney disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478309/
https://www.ncbi.nlm.nih.gov/pubmed/31013316
http://dx.doi.org/10.1371/journal.pone.0215766
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