Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals

Mounting evidence supports that LINE-1 (L1) retrotransposition can occur postzygotically in healthy and diseased human tissues, contributing to genomic mosaicism in the brain and other somatic tissues of an individual. However, the genomic distribution of somatic human-specific LINE-1 (L1Hs) inserti...

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Detalles Bibliográficos
Autores principales: Zhao, Boxun, Wu, Qixi, Ye, Adam Yongxin, Guo, Jing, Zheng, Xianing, Yang, Xiaoxu, Yan, Linlin, Liu, Qing-Rong, Hyde, Thomas M., Wei, Liping, Huang, August Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478352/
https://www.ncbi.nlm.nih.gov/pubmed/30973874
http://dx.doi.org/10.1371/journal.pgen.1008043

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