Cargando…

Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis

SCOPE: Studies have demonstrated inconsistent effects of curcumin on glycemic outcomes and lipid parameters in patients with prediabetes and type 2 diabetes mellitus (T2DM). This study aimed to assess the effect of curcumin on glycemic control and lipid profile in prediabetes and T2DM. METHODS AND R...

Descripción completa

Detalles Bibliográficos
Autores principales: Poolsup, Nalinee, Suksomboon, Naeti, Kurnianta, Putu Dian Marani, Deawjaroen, Kulchalee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478379/
https://www.ncbi.nlm.nih.gov/pubmed/31013312
http://dx.doi.org/10.1371/journal.pone.0215840
_version_ 1783413160209809408
author Poolsup, Nalinee
Suksomboon, Naeti
Kurnianta, Putu Dian Marani
Deawjaroen, Kulchalee
author_facet Poolsup, Nalinee
Suksomboon, Naeti
Kurnianta, Putu Dian Marani
Deawjaroen, Kulchalee
author_sort Poolsup, Nalinee
collection PubMed
description SCOPE: Studies have demonstrated inconsistent effects of curcumin on glycemic outcomes and lipid parameters in patients with prediabetes and type 2 diabetes mellitus (T2DM). This study aimed to assess the effect of curcumin on glycemic control and lipid profile in prediabetes and T2DM. METHODS AND RESULTS: A systematic search of randomized controlled trials (RCTs) was conducted from inception to June 2018 in electronic sources including AMED, ANZCTR, BioMed Central, CENTRAL, CINAHL, ClinicalTrials.gov, Expanded Academic Index, Google Scholar, ISRCTN, LILACS, MEDLINE, NCCIH, Science Direct, Scopus, Web of Science, and WHO ICTRP. Hand search was also performed. Of the total 486 records, four trials (N = 508) and eight trials (N = 646) were eligible for the meta-analysis of individuals with prediabetes and T2DM, respectively. Curcumin significantly reduced glycosylated hemoglobin (HbA1c) in prediabetics (MD: -0.9%, 95% CI: -1.7 to -0.1%, p = 0.03). Furthermore, T2DM subjects gained favorable reduction in both HbA1c (MD: -0.5%, 95% CI: -1.0 to -0.0%, p = 0.04) and fasting plasma glucose (MD: -11.7 mg/dL, 95% CI: -22.1 to -1.3 mg/dL, p = 0.03). Tendency of lipid profile improvement was also observed. CONCLUSION: Our findings may encourage curcumin supplementation based on its meaningful effect on glycemic control and positive trend on lipid outcomes in prediabetes and T2DM.
format Online
Article
Text
id pubmed-6478379
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-64783792019-05-07 Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis Poolsup, Nalinee Suksomboon, Naeti Kurnianta, Putu Dian Marani Deawjaroen, Kulchalee PLoS One Research Article SCOPE: Studies have demonstrated inconsistent effects of curcumin on glycemic outcomes and lipid parameters in patients with prediabetes and type 2 diabetes mellitus (T2DM). This study aimed to assess the effect of curcumin on glycemic control and lipid profile in prediabetes and T2DM. METHODS AND RESULTS: A systematic search of randomized controlled trials (RCTs) was conducted from inception to June 2018 in electronic sources including AMED, ANZCTR, BioMed Central, CENTRAL, CINAHL, ClinicalTrials.gov, Expanded Academic Index, Google Scholar, ISRCTN, LILACS, MEDLINE, NCCIH, Science Direct, Scopus, Web of Science, and WHO ICTRP. Hand search was also performed. Of the total 486 records, four trials (N = 508) and eight trials (N = 646) were eligible for the meta-analysis of individuals with prediabetes and T2DM, respectively. Curcumin significantly reduced glycosylated hemoglobin (HbA1c) in prediabetics (MD: -0.9%, 95% CI: -1.7 to -0.1%, p = 0.03). Furthermore, T2DM subjects gained favorable reduction in both HbA1c (MD: -0.5%, 95% CI: -1.0 to -0.0%, p = 0.04) and fasting plasma glucose (MD: -11.7 mg/dL, 95% CI: -22.1 to -1.3 mg/dL, p = 0.03). Tendency of lipid profile improvement was also observed. CONCLUSION: Our findings may encourage curcumin supplementation based on its meaningful effect on glycemic control and positive trend on lipid outcomes in prediabetes and T2DM. Public Library of Science 2019-04-23 /pmc/articles/PMC6478379/ /pubmed/31013312 http://dx.doi.org/10.1371/journal.pone.0215840 Text en © 2019 Poolsup et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Poolsup, Nalinee
Suksomboon, Naeti
Kurnianta, Putu Dian Marani
Deawjaroen, Kulchalee
Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis
title Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis
title_full Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis
title_fullStr Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis
title_full_unstemmed Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis
title_short Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis
title_sort effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478379/
https://www.ncbi.nlm.nih.gov/pubmed/31013312
http://dx.doi.org/10.1371/journal.pone.0215840
work_keys_str_mv AT poolsupnalinee effectsofcurcuminonglycemiccontrolandlipidprofileinprediabetesandtype2diabetesmellitusasystematicreviewandmetaanalysis
AT suksomboonnaeti effectsofcurcuminonglycemiccontrolandlipidprofileinprediabetesandtype2diabetesmellitusasystematicreviewandmetaanalysis
AT kurniantaputudianmarani effectsofcurcuminonglycemiccontrolandlipidprofileinprediabetesandtype2diabetesmellitusasystematicreviewandmetaanalysis
AT deawjaroenkulchalee effectsofcurcuminonglycemiccontrolandlipidprofileinprediabetesandtype2diabetesmellitusasystematicreviewandmetaanalysis