Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

Unraveling the genetic susceptibility of complex diseases such as chronic kidney disease remains challenging. Here, we used inbred rat models of kidney damage associated with elevated blood pressure for the comprehensive analysis of a major albuminuria susceptibility locus detected in these models....

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Detalles Bibliográficos
Autores principales: Schulz, Angela, Müller, Nicola Victoria, van de Lest, Nina Anne, Eisenreich, Andreas, Schmidbauer, Martina, Barysenka, Andrei, Purfürst, Bettina, Sporbert, Anje, Lorenzen, Theodor, Meyer, Alexander M, Herlan, Laura, Witten, Anika, Rühle, Frank, Zhou, Weibin, de Heer, Emile, Scharpfenecker, Marion, Panáková, Daniela, Stoll, Monika, Kreutz, Reinhold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478434/
https://www.ncbi.nlm.nih.gov/pubmed/30900988
http://dx.doi.org/10.7554/eLife.42068

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