Modulating native GABA(A) receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death

PURPOSE: Pediatric brain cancer medulloblastoma (MB) standard-of-care results in numerous comorbidities. MB is comprised of distinct molecular subgroups. Group 3 molecular subgroup patients have the highest relapse rates and after standard-of-care have a 20% survival. Group 3 tumors have high expres...

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Detalles Bibliográficos
Autores principales: Kallay, Laura, Keskin, Havva, Ross, Alexandra, Rupji, Manali, Moody, Olivia A., Wang, Xin, Li, Guanguan, Ahmed, Taukir, Rashid, Farjana, Stephen, Michael Rajesh, Cottrill, Kirsten A., Nuckols, T. Austin, Xu, Maxwell, Martinson, Deborah E., Tranghese, Frank, Pei, Yanxin, Cook, James M., Kowalski, Jeanne, Taylor, Michael D., Jenkins, Andrew, Pomeranz Krummel, Daniel A., Sengupta, Soma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Laboratory Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478651/
https://www.ncbi.nlm.nih.gov/pubmed/30725256
http://dx.doi.org/10.1007/s11060-019-03115-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478651/
https://www.ncbi.nlm.nih.gov/pubmed/30725256
http://dx.doi.org/10.1007/s11060-019-03115-0

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