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Relevance of ERK1/2 Post-retrieval Participation on Memory Processes: Insights in Their Particular Role on Reconsolidation and Persistence of Memories

Back in 1968, Misanin and his group posited that reactivation of consolidated memories could support changes in that trace, similar to what might happen during the consolidation process. Not until 2000, when Nader et al. (2000) studied the behavioral effect of a protein synthesis inhibitor on retrie...

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Autores principales: Krawczyk, Maria C., Millan, Julieta, Blake, Mariano G., Feld, Mariana, Boccia, Mariano M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478671/
https://www.ncbi.nlm.nih.gov/pubmed/31057366
http://dx.doi.org/10.3389/fnmol.2019.00095
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author Krawczyk, Maria C.
Millan, Julieta
Blake, Mariano G.
Feld, Mariana
Boccia, Mariano M.
author_facet Krawczyk, Maria C.
Millan, Julieta
Blake, Mariano G.
Feld, Mariana
Boccia, Mariano M.
author_sort Krawczyk, Maria C.
collection PubMed
description Back in 1968, Misanin and his group posited that reactivation of consolidated memories could support changes in that trace, similar to what might happen during the consolidation process. Not until 2000, when Nader et al. (2000) studied the behavioral effect of a protein synthesis inhibitor on retrieved memories, could this previous statement be taken under consideration once again; suggesting that consolidated memories can become labile after reactivation. The process of strengthening after memory labilization was named memory reconsolidation. In recent years, many studies pointed towards a critical participation of the extracellular signal-regulated kinase (ERK)/mitogen activated protein kinases (MAPKs) pathway in different memory processes (e.g., consolidation, extinction, reconsolidation, among others). In this review article, we will focus on how this system might be modulating the processes triggered after retrieval of well-consolidated memories in mice.
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spelling pubmed-64786712019-05-03 Relevance of ERK1/2 Post-retrieval Participation on Memory Processes: Insights in Their Particular Role on Reconsolidation and Persistence of Memories Krawczyk, Maria C. Millan, Julieta Blake, Mariano G. Feld, Mariana Boccia, Mariano M. Front Mol Neurosci Neuroscience Back in 1968, Misanin and his group posited that reactivation of consolidated memories could support changes in that trace, similar to what might happen during the consolidation process. Not until 2000, when Nader et al. (2000) studied the behavioral effect of a protein synthesis inhibitor on retrieved memories, could this previous statement be taken under consideration once again; suggesting that consolidated memories can become labile after reactivation. The process of strengthening after memory labilization was named memory reconsolidation. In recent years, many studies pointed towards a critical participation of the extracellular signal-regulated kinase (ERK)/mitogen activated protein kinases (MAPKs) pathway in different memory processes (e.g., consolidation, extinction, reconsolidation, among others). In this review article, we will focus on how this system might be modulating the processes triggered after retrieval of well-consolidated memories in mice. Frontiers Media S.A. 2019-04-17 /pmc/articles/PMC6478671/ /pubmed/31057366 http://dx.doi.org/10.3389/fnmol.2019.00095 Text en Copyright © 2019 Krawczyk, Millan, Blake, Feld and Boccia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Krawczyk, Maria C.
Millan, Julieta
Blake, Mariano G.
Feld, Mariana
Boccia, Mariano M.
Relevance of ERK1/2 Post-retrieval Participation on Memory Processes: Insights in Their Particular Role on Reconsolidation and Persistence of Memories
title Relevance of ERK1/2 Post-retrieval Participation on Memory Processes: Insights in Their Particular Role on Reconsolidation and Persistence of Memories
title_full Relevance of ERK1/2 Post-retrieval Participation on Memory Processes: Insights in Their Particular Role on Reconsolidation and Persistence of Memories
title_fullStr Relevance of ERK1/2 Post-retrieval Participation on Memory Processes: Insights in Their Particular Role on Reconsolidation and Persistence of Memories
title_full_unstemmed Relevance of ERK1/2 Post-retrieval Participation on Memory Processes: Insights in Their Particular Role on Reconsolidation and Persistence of Memories
title_short Relevance of ERK1/2 Post-retrieval Participation on Memory Processes: Insights in Their Particular Role on Reconsolidation and Persistence of Memories
title_sort relevance of erk1/2 post-retrieval participation on memory processes: insights in their particular role on reconsolidation and persistence of memories
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478671/
https://www.ncbi.nlm.nih.gov/pubmed/31057366
http://dx.doi.org/10.3389/fnmol.2019.00095
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