Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes

The CRISPR-Cas9 system has raised hopes for developing personalized gene therapies for complex diseases. Its application for genetic and epigenetic therapies in humans raises concerns over immunogenicity of the bacterially derived Cas9 protein. Here we detect antibodies to Streptococcus pyogenes Cas...

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Detalles Bibliográficos
Autores principales: Ferdosi, Shayesteh R., Ewaisha, Radwa, Moghadam, Farzaneh, Krishna, Sri, Park, Jin G., Ebrahimkhani, Mo R., Kiani, Samira, Anderson, Karen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478683/
https://www.ncbi.nlm.nih.gov/pubmed/31015529
http://dx.doi.org/10.1038/s41467-019-09693-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478683/
https://www.ncbi.nlm.nih.gov/pubmed/31015529
http://dx.doi.org/10.1038/s41467-019-09693-x

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