The TIR/BB-loop mimetic AS-1 prevents Ang II-induced hypertensive cardiac hypertrophy via NF-κB dependent downregulation of miRNA-143

Untreated pathological cardiac hypertrophy, which can be caused by sustained systemic hypertension, may lead to heart failure. In the present study, we investigated whether AS-1 had attenuating effects on hypertension-induced cardiac hypertrophy, and whether this process was mediated by the regulati...

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Detalles Bibliográficos
Autores principales: Song, Juan, Xie, Qifei, Wang, Lin, Lu, Yi, Liu, Peijing, Yang, Ping, Chen, Rui, Shao, Chen, Qiao, Chen, Wang, Zhongqun, Yan, Jinchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478826/
https://www.ncbi.nlm.nih.gov/pubmed/31015570
http://dx.doi.org/10.1038/s41598-019-42936-x

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