Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

Diabetic kidney disease is a major cause of renal failure that urgently necessitates a breakthrough in disease management. Here we show using untargeted metabolomics that levels of phenyl sulfate, a gut microbiota-derived metabolite, increase with the progression of diabetes in rats overexpressing h...

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Detalles Bibliográficos
Autores principales: Kikuchi, Koichi, Saigusa, Daisuke, Kanemitsu, Yoshitomi, Matsumoto, Yotaro, Thanai, Paxton, Suzuki, Naoto, Mise, Koki, Yamaguchi, Hiroaki, Nakamura, Tomohiro, Asaji, Kei, Mukawa, Chikahisa, Tsukamoto, Hiroki, Sato, Toshihiro, Oikawa, Yoshitsugu, Iwasaki, Tomoyuki, Oe, Yuji, Tsukimi, Tomoya, Fukuda, Noriko N., HO, Hsin-Jung, Nanto-Hara, Fumika, Ogura, Jiro, Saito, Ritsumi, Nagao, Shizuko, Ohsaki, Yusuke, Shimada, Satoshi, Suzuki, Takehiro, Toyohara, Takafumi, Mishima, Eikan, Shima, Hisato, Akiyama, Yasutoshi, Akiyama, Yukako, Ichijo, Mariko, Matsuhashi, Tetsuro, Matsuo, Akihiro, Ogata, Yoshiaki, Yang, Ching-Chin, Suzuki, Chitose, Breeggemann, Matthew C., Heymann, Jurgen, Shimizu, Miho, Ogawa, Susumu, Takahashi, Nobuyuki, Suzuki, Takashi, Owada, Yuji, Kure, Shigeo, Mano, Nariyasu, Soga, Tomoyoshi, Wada, Takashi, Kopp, Jeffrey B., Fukuda, Shinji, Hozawa, Atsushi, Yamamoto, Masayuki, Ito, Sadayoshi, Wada, Jun, Tomioka, Yoshihisa, Abe, Takaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478834/
https://www.ncbi.nlm.nih.gov/pubmed/31015435
http://dx.doi.org/10.1038/s41467-019-09735-4

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