Impaired cortico-striatal excitatory transmission triggers epilepsy

STXBP1 and SCN2A gene mutations are observed in patients with epilepsies, although the circuit basis remains elusive. Here, we show that mice with haplodeficiency for these genes exhibit absence seizures with spike-and-wave discharges (SWDs) initiated by reduced cortical excitatory transmission into...

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Detalles Bibliográficos
Autores principales: Miyamoto, Hiroyuki, Tatsukawa, Tetsuya, Shimohata, Atsushi, Yamagata, Tetsushi, Suzuki, Toshimitsu, Amano, Kenji, Mazaki, Emi, Raveau, Matthieu, Ogiwara, Ikuo, Oba-Asaka, Atsuko, Hensch, Takao K., Itohara, Shigeyoshi, Sakimura, Kenji, Kobayashi, Kenta, Kobayashi, Kazuto, Yamakawa, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478892/
https://www.ncbi.nlm.nih.gov/pubmed/31015467
http://dx.doi.org/10.1038/s41467-019-09954-9

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