Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions

Bronchial premalignant lesions (PMLs) are precursors of lung squamous cell carcinoma, but have variable outcome, and we lack tools to identify and treat PMLs at risk for progression to cancer. Here we report the identification of four molecular subtypes of PMLs with distinct differences in epithelia...

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Detalles Bibliográficos
Autores principales: Beane, Jennifer E., Mazzilli, Sarah A., Campbell, Joshua D., Duclos, Grant, Krysan, Kostyantyn, Moy, Christopher, Perdomo, Catalina, Schaffer, Michael, Liu, Gang, Zhang, Sherry, Liu, Hanqiao, Vick, Jessica, Dhillon, Samjot S., Platero, Suso J., Dubinett, Steven M., Stevenson, Christopher, Reid, Mary E., Lenburg, Marc E., Spira, Avrum E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478943/
https://www.ncbi.nlm.nih.gov/pubmed/31015447
http://dx.doi.org/10.1038/s41467-019-09834-2

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