Amelanotic Malignant Melanoma with Dense Pleural Thickening Mimicking Malignant Mesothelioma

A 51-year-old man was diagnosed with stage IIC nodular malignant melanoma (T4bN0M0) of the right upper arm. The tumor was treatment-refractory, and left-sided pleural effusion emerged 1.5 years later. Aspiration of pleural fluid revealed abundant amelanotic, atypical cells that resembled epithelial...

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Autores principales: Saraya, Takeshi, Fujiwara, Masachika, Morita, Kikuko, Watanabe, Takayasu, Ogawa, Yukari, Takizawa, Hajime, Light, Richard W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478975/
https://www.ncbi.nlm.nih.gov/pubmed/30449771
http://dx.doi.org/10.2169/internalmedicine.0867-18
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author Saraya, Takeshi
Fujiwara, Masachika
Morita, Kikuko
Watanabe, Takayasu
Ogawa, Yukari
Takizawa, Hajime
Light, Richard W
author_facet Saraya, Takeshi
Fujiwara, Masachika
Morita, Kikuko
Watanabe, Takayasu
Ogawa, Yukari
Takizawa, Hajime
Light, Richard W
author_sort Saraya, Takeshi
collection PubMed
description A 51-year-old man was diagnosed with stage IIC nodular malignant melanoma (T4bN0M0) of the right upper arm. The tumor was treatment-refractory, and left-sided pleural effusion emerged 1.5 years later. Aspiration of pleural fluid revealed abundant amelanotic, atypical cells that resembled epithelial malignant mesothelioma or lung adenocarcinoma cells; these cells were positive for melanoma-associated antigen recognized by T cells (MART-1)/Melan-A, HMB-45, and S-100 on immunocytochemistry. Thoracic computed tomography (CT) revealed marked diffuse pleural thickening in the left hemithorax that mimicked malignant mesothelioma; thus, the present report describes the unique cytological and radiological findings of this case.
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spelling pubmed-64789752019-04-24 Amelanotic Malignant Melanoma with Dense Pleural Thickening Mimicking Malignant Mesothelioma Saraya, Takeshi Fujiwara, Masachika Morita, Kikuko Watanabe, Takayasu Ogawa, Yukari Takizawa, Hajime Light, Richard W Intern Med Case Report A 51-year-old man was diagnosed with stage IIC nodular malignant melanoma (T4bN0M0) of the right upper arm. The tumor was treatment-refractory, and left-sided pleural effusion emerged 1.5 years later. Aspiration of pleural fluid revealed abundant amelanotic, atypical cells that resembled epithelial malignant mesothelioma or lung adenocarcinoma cells; these cells were positive for melanoma-associated antigen recognized by T cells (MART-1)/Melan-A, HMB-45, and S-100 on immunocytochemistry. Thoracic computed tomography (CT) revealed marked diffuse pleural thickening in the left hemithorax that mimicked malignant mesothelioma; thus, the present report describes the unique cytological and radiological findings of this case. The Japanese Society of Internal Medicine 2018-11-19 2019-04-01 /pmc/articles/PMC6478975/ /pubmed/30449771 http://dx.doi.org/10.2169/internalmedicine.0867-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Saraya, Takeshi
Fujiwara, Masachika
Morita, Kikuko
Watanabe, Takayasu
Ogawa, Yukari
Takizawa, Hajime
Light, Richard W
Amelanotic Malignant Melanoma with Dense Pleural Thickening Mimicking Malignant Mesothelioma
title Amelanotic Malignant Melanoma with Dense Pleural Thickening Mimicking Malignant Mesothelioma
title_full Amelanotic Malignant Melanoma with Dense Pleural Thickening Mimicking Malignant Mesothelioma
title_fullStr Amelanotic Malignant Melanoma with Dense Pleural Thickening Mimicking Malignant Mesothelioma
title_full_unstemmed Amelanotic Malignant Melanoma with Dense Pleural Thickening Mimicking Malignant Mesothelioma
title_short Amelanotic Malignant Melanoma with Dense Pleural Thickening Mimicking Malignant Mesothelioma
title_sort amelanotic malignant melanoma with dense pleural thickening mimicking malignant mesothelioma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478975/
https://www.ncbi.nlm.nih.gov/pubmed/30449771
http://dx.doi.org/10.2169/internalmedicine.0867-18
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