PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1. Although Vpx is phosphorylated, it remains unclear whether such phosphorylation indeed regulates its activity toward SAMHD1. Here we identify the PIM family of serine/threonine p...

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Detalles Bibliográficos
Autores principales: Miyakawa, Kei, Matsunaga, Satoko, Yokoyama, Masaru, Nomaguchi, Masako, Kimura, Yayoi, Nishi, Mayuko, Kimura, Hirokazu, Sato, Hironori, Hirano, Hisashi, Tamura, Tomohiko, Akari, Hirofumi, Miura, Tomoyuki, Adachi, Akio, Sawasaki, Tatsuya, Yamamoto, Naoki, Ryo, Akihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479052/
https://www.ncbi.nlm.nih.gov/pubmed/31015445
http://dx.doi.org/10.1038/s41467-019-09867-7

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