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Association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes

BACKGROUND: The effect of isolated maternal hypothyroxinaemia (IMH) on pregnancy complications and neonatal outcomes in human beings is still controversial. METHODS: This was a retrospective cohort study based on the electronic medical register system. The records of women with a singleton pregnancy...

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Autores principales: Su, Xiujuan, Zhao, Yan, Cao, Zhijuan, Yang, Yingying, Duan, Tony, Hua, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479197/
https://www.ncbi.nlm.nih.gov/pubmed/30889550
http://dx.doi.org/10.1530/EC-19-0088
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author Su, Xiujuan
Zhao, Yan
Cao, Zhijuan
Yang, Yingying
Duan, Tony
Hua, Jing
author_facet Su, Xiujuan
Zhao, Yan
Cao, Zhijuan
Yang, Yingying
Duan, Tony
Hua, Jing
author_sort Su, Xiujuan
collection PubMed
description BACKGROUND: The effect of isolated maternal hypothyroxinaemia (IMH) on pregnancy complications and neonatal outcomes in human beings is still controversial. METHODS: This was a retrospective cohort study based on the electronic medical register system. The records of women with a singleton pregnancy who sought antenatal examination between January 2014 and December 2015 at Shanghai First Maternity and Infant Hospital were extracted from the electronic medical records system. Thyroid-stimulating hormone (TSH), free thyroxine (fT4) and anti-thyroperoxidase autoantibody (TPO-Ab) was measured before 20 gestational weeks, and a multiple logistic regression model was used to estimate the odds ratios of pregnancy complications and neonatal outcomes between euthyroid women and those with isolated hypothyroxinaemia. RESULTS: A total of 8173 women were included in this study, of whom 342 (4.18%) were diagnosed with IMH. Regression analysis showed that IMH diagnosed in the second trimester (13–20 weeks) was associated with an increased risk of hypertensive disorders of pregnancy (OR = 2.66, 95% CI: 1.38–5.10) and placenta abruption (OR = 3.64, 95% CI: 1.07–12.41), but not with preterm delivery (OR = 1.09, 95% CI: 0.50–2.40), small or large gestational age of infant (OR = 0.91, 95% CI: 0.39–2.12; OR = 1.16, 95% CI: 0.72–1.86), macrosomia (OR = 1.71, 95% CI: 0.95–3.07), gestational diabetes mellitus (OR = 1.36, 95% CI: 0.86–2.15) and placenta previa (OR = 1.62, 95% CI: 0.39–7.37). CONCLUSION: IMH could be a risk factor for hypertensive disorders of pregnancy.
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spelling pubmed-64791972019-04-26 Association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes Su, Xiujuan Zhao, Yan Cao, Zhijuan Yang, Yingying Duan, Tony Hua, Jing Endocr Connect Research BACKGROUND: The effect of isolated maternal hypothyroxinaemia (IMH) on pregnancy complications and neonatal outcomes in human beings is still controversial. METHODS: This was a retrospective cohort study based on the electronic medical register system. The records of women with a singleton pregnancy who sought antenatal examination between January 2014 and December 2015 at Shanghai First Maternity and Infant Hospital were extracted from the electronic medical records system. Thyroid-stimulating hormone (TSH), free thyroxine (fT4) and anti-thyroperoxidase autoantibody (TPO-Ab) was measured before 20 gestational weeks, and a multiple logistic regression model was used to estimate the odds ratios of pregnancy complications and neonatal outcomes between euthyroid women and those with isolated hypothyroxinaemia. RESULTS: A total of 8173 women were included in this study, of whom 342 (4.18%) were diagnosed with IMH. Regression analysis showed that IMH diagnosed in the second trimester (13–20 weeks) was associated with an increased risk of hypertensive disorders of pregnancy (OR = 2.66, 95% CI: 1.38–5.10) and placenta abruption (OR = 3.64, 95% CI: 1.07–12.41), but not with preterm delivery (OR = 1.09, 95% CI: 0.50–2.40), small or large gestational age of infant (OR = 0.91, 95% CI: 0.39–2.12; OR = 1.16, 95% CI: 0.72–1.86), macrosomia (OR = 1.71, 95% CI: 0.95–3.07), gestational diabetes mellitus (OR = 1.36, 95% CI: 0.86–2.15) and placenta previa (OR = 1.62, 95% CI: 0.39–7.37). CONCLUSION: IMH could be a risk factor for hypertensive disorders of pregnancy. Bioscientifica Ltd 2019-03-19 /pmc/articles/PMC6479197/ /pubmed/30889550 http://dx.doi.org/10.1530/EC-19-0088 Text en © 2019 The authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Research
Su, Xiujuan
Zhao, Yan
Cao, Zhijuan
Yang, Yingying
Duan, Tony
Hua, Jing
Association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes
title Association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes
title_full Association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes
title_fullStr Association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes
title_full_unstemmed Association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes
title_short Association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes
title_sort association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479197/
https://www.ncbi.nlm.nih.gov/pubmed/30889550
http://dx.doi.org/10.1530/EC-19-0088
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